|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
The FAK/Src/Paxillin (PXN) axis has been implicated in malignant transformation, tumor growth, progression and metastasis.
|
29135089 |
2019 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
In 3LL-D122-metastasis, of mice treated with the best combination, both EGFR and uPAR/α5β1 integrin pathways are turn off (I.e expression of uPAR/α5β1; and phosphorylation of EGFR, Stat3, Src and FAK are reduced); and tumor angiogenesis is decreased.
|
29844873 |
2018 |
|
Neoplasm Metastasis
|
0.300 |
GeneticVariation
|
phenotype |
BEFREE |
ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK-AKT-mTOR Signaling Pathway.
|
30237308 |
2018 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Urokinase-derived peptide UP-7 suppresses tumor angiogenesis and metastasis through inhibition of FAK activation.
|
29515782 |
2018 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, disaggregation of multicellular EOC spheroids, a behavior associated with dissemination and metastasis, is enhanced by matrix stiffness through a mechanotransduction pathway involving ROCK, actomyosin contractility, and FAK.
|
29740072 |
2018 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Moreover, FAK, PI3K, Akt and NF-κB activation were also shown to be involved in CTGF-mediated osteosarcoma metastasis.
|
29909077 |
2018 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Therefore, CX3CL1 and its regulation of the EGFR, Src and FAK pathways may be potential targets for the early prevention of spinal metastasis in prostate cancer.
|
30066854 |
2018 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Meanwhile, action mechanism studies showed that the targeting liposomes could down-regulate PI3K, MMP-2, MMP-9 and FAK to inhibit tumor metastasis.
|
30299160 |
2018 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
MnSOD then converts superoxide into hydrogen peroxide, which activates ERK1/2 to promote tumor cell migration and activates FAK to promote tumor cell adhesion.
|
30193891 |
2018 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
In clinical samples, high FAK and pFAK expressions were associated with KIT mutation status, and high FAK expression was also associated with metastasis in GIST.
|
30149002 |
2018 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
CLCA2 inhibited tumor metastasis through suppressing epithelial-Mesenchymal transition (EMT) and in-activating FAK/ERK1/2 signaling pathway in NPC cells.
|
29463274 |
2018 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
We demonstrated that SMG inhibited cell proliferation/metastasis via FAK/RhoA-regulated mTORC1 pathway.
|
29986550 |
2018 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that blocking FAK-Akt1 interaction may prevent perioperative tumor dissemination and that analogs or mimics of this 7 amino acid FAK-derived peptide could impair metastasis.
|
29228673 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Collectively, these data demonstrate functional activation of FAK1 in metastases and provide preclinical rationale for targeting this kinase in the setting of advanced ccRCC.
|
28418903 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Mechanistically, we determined that FAK were phosphorylated on Tyr397, and were activated by integrin β3, which is important for the CTHRC1-mediated migratory and invasive ability of EOC cells in vitro and i.p. metastasis.
|
29021002 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Gene set enrichment analysis (GSEA) showed that metastasis, cell cycle and FAK pathways were related with elevated CKAP2 expression.
|
28522860 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Overexpression of miR-466 caused a marked downregulation of integrated network of RUNX2 target genes such as osteopontin, osteocalcin, ANGPTs, MMP11 including Fyn, pAkt, FAK and vimentin that are known to be involved in migration, invasion, angiogenesis, EMT and metastasis.
|
28125091 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Lycorine inhibits breast cancer growth and metastasis via inducing apoptosis and blocking Src/FAK-involved pathway.
|
28251459 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
As recent reports imply that FAK1 is highly associated with tumor cell development and malignancy, the inhibition of FAK1 activity could be an effective therapeutic approach for inhibiting the growth and metastasis of tumor cells.
|
29048635 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Cells adorned with longer glycopolymers showed increased metastatic potential, enhanced cell cycle progression, and greater levels of integrin-FAK mechanosignaling and Akt signaling in a syngeneic mouse model of metastasis.
|
29266001 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway.
|
27644693 |
2016 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, AURKA may induce EMT to promote metastasis via activation of the FAK/PI3K pathway in LSCC.
|
27373675 |
2016 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
SMARCE1-mediated PTK2 activation likely plays a key role in promoting metastasis of basal-like and luminal B subtype of breast tumors.
|
27495308 |
2016 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
RT-PCR assays of OS cells incubated with extracellular vesicles (EVs) from SD-MSCs revealed microRNAs that could potentially target metabolism and metastasis associated genes as predicted by in silico algorithms, including monocarboxylate transporters, bone morphogenic receptor type 2, fibroblast growth factor 7, matrix metalloproteinase-1, and focal adhesion kinase-1.
|
27812189 |
2016 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Therefore, phosphorylated FAK Y861 and increased Yes expression may be predictive markers for PCa metastasis.
|
25868388 |
2015 |