Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.050 AlteredExpression group BEFREE The conformational switch of MDA5 causes antiviral defense, but excessive activation of the MDA5-MAVS pathway may result in autoimmune diseases. 29069650 2018
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.050 Biomarker group BEFREE Mitochondrial antiviral signaling (MAVS) protein has an important role in antiviral immunity and autoimmunity. 28141795 2017
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.050 GeneticVariation group BEFREE Persistent MAVS aggregates may lead to increased type I IFN production and result in unmitigated signals leading to autoimmunity. 27110677 2016
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.050 AlteredExpression group BEFREE Excessive activation of MAVS-mediated antiviral signaling leads to dysfunction of mitochondria and cell apoptosis that likely causes the pathogenesis of autoimmunity. 23308066 2012
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.050 Biomarker group BEFREE Here, we hypothesized that altered expression or function of MAVS, a key molecule downstream of the viral sensors RIG-I and MDA-5, may impair antiviral cell signalling and thereby influence the risk for systemic lupus erythematosus (SLE), the prototype autoimmune disease. 21268286 2011