BAX, BCL2 associated X, apoptosis regulator, 581

N. diseases: 420; N. variants: 9
Disease: Kidney Failure, Acute ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.310 AlteredExpression disease BEFREE Cisplatin induced mtDNA leakage into the cytosol-probably through BCL-2-like protein 4 (BAX) pores in the mitochondrial outer membrane-in tubules, with subsequent activation of the cGAS-STING pathway, thereby triggering inflammation and AKI progression, which is improved in STING-deficient mice. 31665638 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.310 Biomarker disease CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750 2011