PVALB, parvalbumin, 5816

N. diseases: 148; N. variants: 0
Disease: Epileptic Seizures ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4317109
Disease: Epileptic Seizures
Epileptic Seizures 		0.320 AlteredExpression phenotype BEFREE We previously reported predominant Nav1.1 expression in parvalbumin-expressing (PV+) inhibitory neurons in juvenile mouse brain and observed epileptic seizures in mice with selective deletion of Scn1a in PV+ cells mediated by PV-Cre transgene expression (Scn1a<sup>fl/+</sup>/PV-Cre-TG). 29337050 2018
CUI: C4317109
Disease: Epileptic Seizures
Epileptic Seizures 		0.320 Biomarker phenotype CTD_human Hyperthermic seizure induces persistent alteration in excitability of the dentate gyrus in immature rats. 18495095 2008
CUI: C4317109
Disease: Epileptic Seizures
Epileptic Seizures 		0.320 Biomarker phenotype BEFREE Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. 17537961 2007