Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Paxillin and FAK activity are reduced in lung cancer cell lines following wiskostatin and nWASP knockdown as shown by immunofluorescence and western blot.
|
28351346 |
2017 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
EL decreased phosphorylation of FAK and its downstream targets, Src, paxillin, and decreased mRNA expression of cell motility-related genes, RhoA, Rac1, and Cdc42 in lung cancer cells.
|
28068967 |
2017 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we provide evidence indicating that paxillin (PXN) overexpression may confer TKI resistance in EGFR-mutant lung cancer cells.
|
25915848 |
2016 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The data reported herein suggest that mutant PXN variants play a prominent role in mitochondrial dynamics with direct implications on lung cancer progression and hence, deserve further exploration as therapeutic targets.
|
23792636 |
2013 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
RIE also inhibited p-FAK, p-paxillin and AP-1 by Western blot analysis, indicating the anti-EMT effect of RIE in human lung carcinoma.
|
24161487 |
2013 |
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Paxillin overexpression occurs during the earliest stages of lung cancer development.
|
21045234 |
2011 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Absence of paxillin gene mutation in lung cancer and other common solid cancers.
|
21617717 |
2011 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
MET, HGF, EGFR, and PXN gene copy number in lung cancer using DNA extracts from FFPE archival samples and prognostic significance.
|
19817696 |
2009 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
The paxillin gene (PXN) encodes a focal adhesion associated protein that could be involved in the progression of lung cancer through its interactions with the actin cytoskeleton and key signal transduction oncogenes.
|
19353596 |
2009 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results establish an important role for paxillin in lung cancer.
|
18172305 |
2008 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
H(2)O(2) treatment of SCLC cells (over 15 min) led to phosphorylation of c-Met receptor tyrosine kinase and further upregulated downstream phosphorylation of phospho-AKT, ERK1/2, and paxillin in a dose-dependent manner (125 microM to 500 microM). c-Met is an important target in lung cancer, and the pathways responsible for ROS generation together may provide novel therapeutic intervention.
|
17322284 |
2007 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
The possible role of paxillin in lung cancer cells was assessed by overexpressing green fluorescence protein (GFP)-paxillin construct in two separate NSCLC cell lines (Calu-1 and H661).
|
9926921 |
1999 |