Malignant neoplasm of breast
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In our study, we evaluted the relation between DNA repair gene polymorphisms XRCC1 rs1799782, rs25487, rs25489; XPC rs2228000, rs2228001; XPD rs1799793, rs13181; XRCC3 rs861539; RAD51B rs10483813, rs1314913 and breast cancer risk for 202 Turkish cases in total, in which 102 patients with breast cancer and 100 controls.
|
28983784 |
2019 |
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In our study, we evaluted the relation between DNA repair gene polymorphisms XRCC1 rs1799782, rs25487, rs25489; XPC rs2228000, rs2228001; XPD rs1799793, rs13181; XRCC3 rs861539; RAD51B rs10483813, rs1314913 and breast cancer risk for 202 Turkish cases in total, in which 102 patients with breast cancer and 100 controls.
|
28983784 |
2019 |
Malignant neoplasm of breast
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Many of the known breast cancer risk variants were associated with young-onset breast cancer, with evidence that TOX3, ESR1, FGFR2, and RAD51B are important for young-onset disease.
|
27848153 |
2017 |
Malignant neoplasm of breast
|
0.500 |
Biomarker
|
disease |
BEFREE |
RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3) have recently been involved in breast and ovarian cancer predisposition: RAD51B, RAD51C, and RAD51D in ovarian cancer, RAD51B and XRCC2 in breast cancer.
|
29255180 |
2017 |
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Many of the known breast cancer risk variants were associated with young-onset breast cancer, with evidence that TOX3, ESR1, FGFR2, and RAD51B are important for young-onset disease.
|
27848153 |
2017 |
Breast Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, and XRCC3) have recently been involved in breast and ovarian cancer predisposition: RAD51B, RAD51C, and RAD51D in ovarian cancer, RAD51B and XRCC2 in breast cancer.
|
29255180 |
2017 |
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
Malignant neoplasm of breast
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In addition, we studied the known rs999737, rs2588809, and rs1314913 SNPs and RAD51B haplotypes in 44,791 breast cancer cases and 43,583 controls from 40 studies participating in the Breast Cancer Association Consortium (BCAC) that were genotyped on a custom chip (iCOGS).
|
27149063 |
2016 |
Malignant neoplasm of breast
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two components of the complex, RAD51C and RAD51D, increase the risk of ovarian cancer especially, and the other two, RAD51B and XRCC2 have been associated with breast cancer risk.
|
26351136 |
2016 |
Malignant neoplasm of breast
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We observed a significant inverse association (P=8.75 × 10(-6); FDR=0.001) between the risk allele in rs2588809 of the gene RAD51B and TSMC across all breast cancer patients, for both ER(+) and ER(-) tumours.
|
27467053 |
2016 |
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two components of the complex, RAD51C and RAD51D, increase the risk of ovarian cancer especially, and the other two, RAD51B and XRCC2 have been associated with breast cancer risk.
|
26351136 |
2016 |
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.
|
27197191 |
2016 |
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In addition, we studied the known rs999737, rs2588809, and rs1314913 SNPs and RAD51B haplotypes in 44,791 breast cancer cases and 43,583 controls from 40 studies participating in the Breast Cancer Association Consortium (BCAC) that were genotyped on a custom chip (iCOGS).
|
27149063 |
2016 |
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We observed a significant inverse association (P=8.75 × 10(-6); FDR=0.001) between the risk allele in rs2588809 of the gene RAD51B and TSMC across all breast cancer patients, for both ER(+) and ER(-) tumours.
|
27467053 |
2016 |
Malignant neoplasm of breast
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus RAD51B is a good candidate melanoma susceptibility gene, and previously, a germline splicing mutation in RAD51B has been identified in a family with early-onset breast cancer.
|
25600502 |
2015 |
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus RAD51B is a good candidate melanoma susceptibility gene, and previously, a germline splicing mutation in RAD51B has been identified in a family with early-onset breast cancer.
|
25600502 |
2015 |
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
Malignant neoplasm of breast
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Large-scale genome-wide association studies (GWAS) have been conducted and reported the association between rs999737 polymorphism at 14q24.1 (RAD51L1) and breast cancer risk.
|
24729084 |
2014 |
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Large-scale genome-wide association studies (GWAS) have been conducted and reported the association between rs999737 polymorphism at 14q24.1 (RAD51L1) and breast cancer risk.
|
24729084 |
2014 |
Malignant neoplasm of breast
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Seven SNPs were statistically significant (P ≤ 0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/TERT), rs999737 (14q24/RAD51L1), rs13387042 (2q35/TNP1), rs1219648 (10q26/FGFR2), rs8170 (19p13/BABAM1), rs17817449 (16q12/FTO), and rs13329835 (16q23/DYL2).
|
23593120 |
2013 |
Malignant neoplasm of breast
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
Malignant neoplasm of breast
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Germline mutation in the RAD51B gene confers predisposition to breast cancer.
|
24139550 |
2013 |
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Seven SNPs were statistically significant (P ≤ 0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/TERT), rs999737 (14q24/RAD51L1), rs13387042 (2q35/TNP1), rs1219648 (10q26/FGFR2), rs8170 (19p13/BABAM1), rs17817449 (16q12/FTO), and rs13329835 (16q23/DYL2).
|
23593120 |
2013 |
Breast Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Germline mutation in the RAD51B gene confers predisposition to breast cancer.
|
24139550 |
2013 |