RB1, RB transcriptional corepressor 1, 5925

N. diseases: 339; N. variants: 239
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.360 AlteredExpression phenotype BEFREE Additionally, resveratrol treatment inhibited SG-mediated Rbfox2 localization, further inhibiting RB1 protein expression, and inhibited specific Rbfox2 localization to the cytoplasm in melanoma B16-F10 cells, thereby effectively inhibiting metastasis and tumor growth ability. 31028247 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.360 Biomarker phenotype BEFREE Interestingly, ectopic expression of miR-200b in the Caki-1 and OSRC-2 cell lines suppresses cell migration and invasion in vitro as well as tumor metastases in vivo. 31130475 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.360 Biomarker phenotype BEFREE Forest plots resulting from our meta-analyses illustrate that loss of RB1 function results in a 1.62-fold increase in the mortality rate for osteosarcoma patients (RR = 1.62, 95% CI: 1.23-2.13; Z = 3.44, P = 0.0006), a significant increase in osteosarcoma metastasis (OR = 3.95, 95% CI: 1.86-8.38; Z = 3.57; P = 0.0004), and a significant reduction in the histological response of osteosarcoma to chemotherapy (OR = 0.35; 95% CI: 0.13-0.94; Z = -2.08; P = 0.038). 26503016 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.360 Biomarker phenotype CTD_human Ezrin Inhibition Up-regulates Stress Response Gene Expression. 27137931 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.360 AlteredExpression phenotype BEFREE Instead, we identified deletion of the p16 (CDKN2A) and retinoblastoma (RB1) genes as likely causal events leading to increased AURKA and CINSARC gene expression, to chromosome rearrangement, and ultimately to metastasis. 22167411 2012
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.360 GeneticVariation phenotype BEFREE The results provided further evidence for the putative role of the RB1 gene alterations in the metastatic process, although a contribution by other gene(s) during metastasis cannot be ruled out. 12377414 2002
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.360 Biomarker phenotype BEFREE Furthermore, the RB1 gene is unlikely to be involved in the suppression of metastasis evident in this system. 12085104 2002