Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Effect of NF-Bp65 inhibitor (BAY-117082) on the proliferation and expression level of Cyclin D1 and PLD2 of colon cancer cells under hypoxic conditions were further analysised.
|
30091007 |
2018 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Curcumol caused cell cycle arrest at the G0/G1 phase by ROS production and Akt/ GSK3β/cyclin D1 pathways inactivation, indicating the potential of curcumol in the prevention of colon cancer carcinogenesis.
|
28684297 |
2018 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Fluorescence in situ hybridization analysis confirms the expression of CCND1 in colon cancer while immunofluorescence analysis confirms the CDK4 in diabetes.
|
30462152 |
2018 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
As revealed by Western blot, the expression of CDK2 and Cyclin D1 was down-regulated in all three Vglycin-treated colon cancer cells, indicating that the CDK2/Cyclin D1 cell cycle pathway involved in the initiation and progression of colon cancer.
|
28492347 |
2017 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway.
|
27191497 |
2016 |
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The cyclin D1 (CCND1) rs9344 G>A polymorphism predicts clinical outcome in colon cancer patients treated with adjuvant 5-FU-based chemotherapy.
|
23567490 |
2014 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In light of these observations, we investigated the association of T-Antigen and nuclear β-catenin in colon cancer cases and the effects of this complex in the activation of the transcription and cell cycle regulators c-Myc and Cyclin D1 in vitro.
|
25229241 |
2014 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
The downstream genes regulated by miR-147 were assayed using the Affymetrix GeneChip U133 Plus2.0 platform. miR-147 was identified to: 1. cause MET primarily by increasing the expression of CDH1 and decreasing that of ZEB1; 2. inhibit the invasion and motility of cells; 3. cause G1 arrest by up-regulating p27 and down-regulating cyclin D1. miR-147 also dramatically reversed the native drug resistance of the colon cancer cell line HCT116 to gefitinib. miR-147 significantly repressed Akt phosphorylation, and knockdown of Akt with siRNA induced MET.
|
24454732 |
2014 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hath1 inhibits proliferation of colon cancer cells probably through up-regulating expression of Muc2 and p27 and down-regulating expression of cyclin D1.
|
23464457 |
2012 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, we demonstrated that SCC-S2 is overexpressed in colon cancers and contributes to malignant cell growth by cyclin D1 and phospho-Rb modulation, which makes SCC-S2 a candidate therapeutic target in colon cancer.
|
22886548 |
2012 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our study found that CARMA3 is overexpressed in colon cancers and contributes to malignant cell growth by facilitating cell cycle progression through NF-κB mediated upregulation of cyclin D1.
|
22884800 |
2012 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
CTD_human |
Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate.
|
21081470 |
2011 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results showed that small interfering RNA directed against β-catenin markedly inhibited the expression and nuclear translocation of β-catenin and decreased the expression of known target genes such as cyclin D1 and c-myc; HT-29 cell proliferation was inhibited as indicated by growth reduction, cell cycle arrest in G0/G1 phase, and induction of apoptosis; and the inhibition of cell growth may be associated with switching off cyclin D1 and c-myc expression by small interfering RNA targeted against β-catenin in colon cancer HT-29 cells.
|
20950152 |
2010 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Forty-eight-hour treatment of colon cancer HCT-116 and HT-29 cells with FOLFOX resulted in 60-70% survival, accompanied by a marked activation of insulin like growth factor-1 receptor (IGF-1R) and minor to moderate increase in epidermal growth factor receptor (EGFR), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 (HER-2) as well as v-akt murine thymoma viral oncogene homolog 1 (AKT), cyclooxygenase-2 (COX-2) and cyclin-D1.
|
20332435 |
2010 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway.
|
19440933 |
2009 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
CTD_human |
gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity.
|
19147571 |
2009 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Collectively, this study demonstrates that over-expression of DIXDC1 might target p21 and cyclin D1 to promote colon cancer cell proliferation and tumorigenesis at least partially through activation of the PI3K/Akt pathway.
|
19572978 |
2009 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Previous studies have identified cyclin D1 as a major target in the antiproliferative effects of PKCalpha in non-transformed intestinal cells; however, a link between PKC signaling and cyclin D1 in colon cancer remained to be established.
|
19232344 |
2009 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
CTD_human |
Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer.
|
21188121 |
2009 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
While APC/beta-CATENIN-dependent expression of CYCLIN D1 was observed in vivo and in vitro, expression of PPAR beta/delta was not different in colon or intestinal polyps from wild-type or Apc(min) heterozygous mice or in human colon cancer cell lines with mutations in APC and/or beta-CATENIN.
|
19415698 |
2009 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1 overexpression is associated with longer survival in colon cancer.
|
19549773 |
2009 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
CTD_human |
Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat.
|
18283038 |
2008 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results show that low concentrations of DCA (5 and 50 microM) significantly increase tyrosine phosphorylation of beta-catenin, induce urokinase-type plasminogen activator, uPAR, and cyclin D1 expression and enhance colon cancer cell proliferation and invasiveness.
|
15004225 |
2004 |
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Whereas our data do not support a modifying role of A versus G allele of CCND1, the results do suggest that the relative abundance of a and b transcripts may modify the age at onset of colon cancer in hereditary nonpolyposis colorectal cancer.
|
11507050 |
2001 |