|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
Identification of CD5/Cyclin D1 Double-negative Pleomorphic Mantle Cell Lymphoma: A Clinicopathologic, Genetic, and Gene Expression Study.
|
31688139 |
2020 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Regulation of SOX11 expression through CCND1 and STAT3 in mantle cell lymphoma.
|
30530749 |
2019 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, we report 3 cases of nodal PMBL, 2 of them without mediastinal mass, and expression of cyclin D1 due to copy number gains of CCND1 gene, a diagnostic pitfall with mantle cell lymphoma and DLBCL, not otherwise specified.
|
30211726 |
2019 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
When cyclin D1 was overexpressed by the Eμ-cyclin D1 transgene, ATA B cells progressed to further diffused lymphoma in aged mice, including in various lymph nodes with accumulation of IgM<sup>hi</sup>IgD<sup>lo</sup>CD5<sup>+</sup>CD23<sup>-</sup>CD43<sup>+</sup> cells, resembling aggressive human mantle cell lymphoma.
|
29898964 |
2018 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA.
|
30180865 |
2018 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1 mRNA as a molecular marker for minimal residual disease monitoring in patients with mantle cell lymphoma.
|
29273915 |
2018 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, cyclin D1 overexpression sensitized cells to transcription inhibitors, revealing a synthetic lethality interaction that was also observed in primary mantle cell lymphoma cases.
|
29990311 |
2018 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cyclin D1 depletion induces DNA damage in mantle cell lymphoma lines.
|
27338091 |
2017 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cyclin D1-positive tumor cells are commonly found in mantle cell lymphoma but they are very rare in diffuse large B-cell lymphoma.
|
28296741 |
2017 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
Role of SOX11 and Genetic Events Cooperating with Cyclin D1 in Mantle Cell Lymphoma.
|
28466437 |
2017 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mantle cell lymphoma with a novel t(11;12)(q13;p11.2): a proposed alternative mechanism of CCND1 up-regulation.
|
28132860 |
2017 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1 protein expression in lymphocytes is classically associated with mantle cell lymphoma.
|
28038705 |
2017 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma.
|
27713153 |
2016 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
Biomarker
|
disease |
CTD_human |
Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas.
|
26174628 |
2016 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Translocation t(11;14)(q13;q32) CCND1-IGH is typically associated with mantle cell lymphoma or a subset of plasma cell myeloma and is exceedingly rare in myeloid neoplasm.
|
27810077 |
2016 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma.
|
27025456 |
2016 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
Quantitative PCR detection of t(11;14) bcl-1/JH in mantle cell lymphoma patients: comparison of peripheral blood and bone marrow aspirate samples.
|
26744872 |
2015 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Detection of t(12;14)(p13;q32) in a patient with IGH-CCND1 negative mantle cell lymphoma resembling ultra-high risk chronic lymphocytic leukemia.
|
26261659 |
2015 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Unusual concomitant rearrangements of Cyclin D1 and MYC genes in blastoid variant of mantle cell lymphoma: Case report and review of literature.
|
23313364 |
2013 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
CCND2 rearrangements are the most frequent genetic events in cyclin D1(-) mantle cell lymphoma.
|
23255553 |
2013 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1 (CCND1) messenger RNA expression as assessed by real-time PCR contributes to diagnosis and follow-up control in patients with mantle cell lymphoma.
|
24060591 |
2013 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cyclin D1-negative mantle cell lymphoma.
|
23429984 |
2013 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The recognition of cyclin D1 expression in PC of a significant minority of CLL/SLL can be a diagnostic aid and should not lead to the diagnosis of focal mantle cell lymphoma.
|
22706868 |
2012 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mantle cell lymphoma is a B cell malignancy in which constitutive dysregulation of cyclin D1 and the cell cycle, disruption of DNA damage response pathways, and activation of cell survival mechanisms contribute to oncogenesis.
|
23023712 |
2012 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.400 |
Biomarker
|
disease |
BEFREE |
Flipping the cyclin D1 switch in mantle cell lymphoma.
|
22687450 |
2012 |