|
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among the down-regulated miRNAs in SCI, 21, 19 and 20 miRNAs were potentially associated with hematological, bladder and esophageal cancer, respectively, and three target genes (<i>TP53, CCND1 and KRAS</i>) were common to all three types of cancer.
|
31444279 |
2019 |
|
Malignant neoplasm of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of plasma miR-93-5p expression significantly increases the risk of esophageal cancer and is associated with poor prognosis. miR-93-5p transferred by exosomes promotes the proliferation of recipient esophageal cancer cells and affects the expression of PTEN and its downstream proteins p21 and cyclin D1.
|
29673440 |
2018 |
|
Malignant neoplasm of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Pin1 is a critical therapeutic and preventive target in esophageal cancer because of its positive regulation of β-catenin and cyclin D1.
|
28325828 |
2017 |
|
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
To elucidate the molecular functions of cyclin D1 on EMT phenotypes and esophageal cancer radiosensitivity, we treated the radioresistant esophageal cancer cells (KYSE-150R) and parental cells (KYSE-150) with cyclin D1 small interfering RNA (siRNA).
|
26561473 |
2016 |
|
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
We utilized a murine esophageal cancer cell line established from the ED-L2-cyclin D1;p53 mouse that was transduced to express a viral tumor antigen, the Human Papilloma Virus (HPV) E7 protein.
|
24810640 |
2014 |
|
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggested that CCND1 amplification and co-alternation of CCND1(+) /pRb(-) /ppRb(+) may play a crucial role in the prognostic evaluation of patients with esophageal cancer, and the patients with CCND1(+) /pRb(-) /ppRb(+) have the worst prognosis in all the patients.
|
22150974 |
2013 |
|
Malignant neoplasm of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, S6 and S6 kinase 1 knockdown resulted in attenuation of viability by suppressing cyclin D1 expression in esophageal cancer cells.
|
22996377 |
2013 |
|
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Promising markers that emerged for the prediction of overall survival in esophageal squamous cell cancer included VEGF (18 eligible studies, n=1476, HR=1.85, 95% CI, 1.55-2.21), cyclin D1 (12 eligible studies, n=1476, HR=1.82, 95% CI, 1.50-2.20), Ki-67 (3 eligible studies, n=308, HR=1.11, 95% CI, 0.70-1.78) and squamous cell carcinoma antigen (5 eligible studies, n=700, HR=1.28, 95% CI, 0.97-1.69); prognostic markers for esophageal adenocarcinoma included COX-2 (2 eligible studies, n=235, HR=3.06, 95% CI, 2.01-4.65) and HER-2 (3 eligible studies, n=291, HR=2.15, 95% CI, 1.39-3.33); prognostic markers for uncategorized ECs included p21 (9 eligible studies, n=858, HR=1.27, 95% CI, 0.75-2.16), p53 (31 eligible studies, n=2851, HR=1.34, 95% CI, 1.21-1.48), CRP (8 eligible studies, n=1382, HR=2.65, 95% CI, 1.64-4.27) and hemoglobin (5 eligible studies, n=544, HR=0.91, 95% CI, 0.83-1.00).
|
24206575 |
2013 |
|
Malignant neoplasm of esophagus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Taken together, our results suggest that the CCND1 G870A polymorphism might not be a potential candidate for predicting esophageal cancer risk.
|
23661400 |
2013 |
|
Malignant neoplasm of esophagus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The overall data suggest that CCND1 G870A variation might have an association with increased esophageal cancer susceptibility.
|
23020291 |
2012 |
|
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Results suggest that TC21 mediates its effects via the PI3K-Akt pathway, NF-κB and cyclin D1, and enhances chemoresistance in esophageal cancer cells.
|
22919244 |
2012 |
|
Malignant neoplasm of esophagus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We developed two mouse models of esophageal cancer by inoculating immunocompetent mice with syngeneic esophageal cell lines transformed by cyclin-D1 or mutant HRAS(G12V) and loss of p53.
|
21869822 |
2011 |
|
Malignant neoplasm of esophagus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In CCND1 G870A polymorphism, the AA genotype was marginally associated with higher risk of esophageal cancer (OR 1.5, 95%CI=0.98-2.4, P=0.05).
|
17561354 |
2007 |
|
Malignant neoplasm of esophagus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To determine whether cyclin D1 is subject to mutations that inhibit its nuclear export in human cancer, we have sequenced exon 5 of cyclin D1 in primary esophageal carcinoma samples and in cell lines derived from esophageal cancer.
|
16732330 |
2006 |
|
Malignant neoplasm of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cyclin D1 overexpression in esophageal cancer from southern China and its clinical significance.
|
16051426 |
2006 |
|
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of Egr-1, c-fos and cyclin D1 in esophageal cancer and its precursors: An immunohistochemical and in situ hybridization study.
|
14966901 |
2004 |
|
Malignant neoplasm of esophagus
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The CCND1-EMS1 locus on human chromosome 11q13 is amplified in esophageal cancer, bladder tumors, and breast cancer.
|
12739008 |
2003 |
|
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increased DNA content and heteroploid rate, accumulation of p53 protein, and over-expression of p21, telomerase and cyclin D1 proteins were early molecular events during the development of esophageal cancer.
|
14606066 |
2003 |
|
Malignant neoplasm of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We examined the possible role of cyclin D1 overexpression on specific malignant properties of tumor cells using a series of eight human esophageal cancer cell lines that express different levels of cyclin D1.
|
12014632 |
2002 |
|
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
CTD_human |
Whereas L2D1(+) mice exhibit a histologic phenotype of oral-esophageal dysplasia, the combination of cyclin D1 expression and p53 deficiency results in invasive oral-esophageal cancer.
|
12235107 |
2002 |
|
Malignant neoplasm of esophagus
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Amplification of the cyclin D1 gene is a reliable prognostic factor and post-translational modification of this gene may play a functionally important role in development of primary esophageal cancer.
|
9458316 |
1998 |
|
Malignant neoplasm of esophagus
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cyclin D1 amplification was detected by FISH in 65% of esophageal cancers.
|
9042789 |
1997 |
|
Malignant neoplasm of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that cyclin D1 may play an important role in carcinogenesis and that cyclin D1 overexpression may be a useful prognostic factor in esophageal cancer.
|
7747810 |
1995 |
|
Malignant neoplasm of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To further address the roles of cyclin D1 in growth control and tumorigenesis, we have overexpressed an antisense cyclin D1 cDNA construct, either constitutively or inducibly, in the HCE7 human esophageal cancer cell line in which cyclin D1 is amplified and expressed at high levels.
|
7630641 |
1995 |
|
Malignant neoplasm of esophagus
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.
|
8415648 |
1993 |