Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Overexpression of CD 133 and BCL-2 in non-small cell lung cancer with neuroendocrine differentiation after transformation in ALK rearrangement-positive adenocarcinoma.
|
30900377 |
2019 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Bcl-2 overexpression is commonly associated with various cancers including breast cancer, prostate cancer, B-cell lymphomas and colorectal adenocarcinomas etc.
|
31494078 |
2019 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Finally, Birinapant and AT-406 can synergise with BCL-2 inhibitor ABT-199 to reduce viability of adenocarcinoma cells with high BCL-2 expression.
|
27520705 |
2016 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This study initially scheduled to determine the expression of bcl2 gene in tissue samples of adenocarcinoma cancer patients.
|
26320497 |
2015 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Expression of ITGB3 and BCL-2 in lung adenocarcinoma and adenocarcinoma cell line showed heterogeneity that expression in trailing edge was higher than that of trailing edge, which may play an important role in promoting tumor lymph node metastasis and vascular invasion, and provides a new research direction for exploration of lung adenocarcinoma metastasis mechanism.
|
25066397 |
2014 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Whereas a balance was observed between the immunoreactivities of Bcl-2 and Bax in the borderline cases, and this balance was strongly changed toward the anti-apoptotic Bcl-2 protein in patients with adenocarcinoma.
|
25108507 |
2014 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Bcl-w a pro-survival member of the Bcl-2 protein family, is expressed in a variety of cancer types, including gastric and colorectal adenocarcinomas, as well as glioblastoma multiforme (GBM), the most common and lethal brain tumor type.
|
23826359 |
2013 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The relationship between up-regulation of p53 and Bcl-2 and poorly differentiated ethmoidal adenocarcinoma suggests a role of these genes, in combination with additional genetic events, in the pathogenesis of ITAC.
|
21978692 |
2011 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma.
|
21472143 |
2011 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The balance between proliferation and apoptosis is represented by changes in the expression of the tissue markers, Bcl-2 and p53, and the presence of silver-stained nucleolar organizing regions (AgNOR) on DNA in prostate adenocarcinomas.
|
20146885 |
2010 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Statistically significant associations between high Ki67 and poorly differentiated tumors (P = 0.016) and a smoking history (P = 0.053); p53 positivity and high Ki67 (P = 0.002); HER-2 positivity and adenocarcinoma subtype (P = 0.015) and presence of lymph node involvement (P = 0.006); and Bcl-2 positivity and squamous cell carcinoma subtype (P = 0.058) were observed.
|
18705409 |
2008 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
LHGDN |
Ki-67, p53 and bcl-2 analysis in colonic versus rectal adenocarcinoma.
|
18516322 |
2008 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Analyses of Bcl-2, Survivin, and CD44v6 expressions and human papillomavirus infection in cervical carcinomas.
|
17464868 |
2007 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Expression of both bcl-2 and cox-2 were increased in non-dysplastic Barrett's (p = 0.0077, p = 0.0037), intraepithelial neoplasia (p = 0.0053, p = 0.0220) and adenocarcinoma (p < 0.0001, p < 0.0001) compared to squamous epithelium or reflux-esophagitis.
|
16550596 |
2006 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Apoptotic index or a combination of Bax/Bcl-2 expression correlate with survival after resection of pancreatic adenocarcinoma.
|
16173075 |
2006 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Multiple apoptotic stimuli induce conformational changes in Bax, a proapoptotic protein from the Bcl-2 family and its deficiency is a frequent cause of chemoresistance in colon adenocarcinomas.
|
15661804 |
2005 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Up-regulation of bcl-2 was found in all CAR-expressing adenocarcinomas of the murine cancer model.
|
15958612 |
2005 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Loss of pSer70 Bcl-2 expression was observed in adenocarcinomas in a differentiation-dependent manner (positivities: well differentiated 63%, moderately differentiated 52%, and poorly differentiated 12%), whereas tubular adenomas maintained their expression (positivity 88%).
|
16243795 |
2005 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Meanwhile, the expressions of Bcl-2 and Bcl-x(L) protein and their mRNAs were significantly higher in adenocarcinoma tissues than that in adenomatous and normal epithelial tissues.
|
15484295 |
2004 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In H pylori positive specimens, expressions of Bid and Bax did not correlate with that of Bcl-2 in adenocarcinoma tissues (Bid vs Bcl-2, r=0.187, P>0.05; Bax vs Bcl-2, r=0.201, P>0.05), but correlated positively with that of Bcl-2 respectively in resection margin tissues (Bid vs Bcl-2, r=0.331, P<0.05; Bax vs Bcl-2, r=0.295, P<0.05).
|
14716828 |
2004 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
This study investigated the prognostic significance of TUNEL, bcl-2, p53, proliferation marker Ki-67 and DNA mismatch repair (MMR) status in patients with Dukes' stage B2 and C colorectal adenocarcinomas.
|
15117979 |
2004 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
A molecular understanding of both the progression of Barrett's esophagus and the factors determining the response of adenocarcinoma to neoadjuvant therapy is required, and this study focused on the role of proteins regulated by the bcl-2 family of genes, which are important regulators of programmed cell death (apoptosis).
|
12581249 |
2003 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
A molecular understanding of both the progression of Barrett's esophagus and the factors determining the response of adenocarcinoma to neoadjuvant therapy is required, and this study focused on the role of proteins regulated by the bcl-2 family of genes, which are important regulators of programmed cell death (apoptosis).
|
12581249 |
2003 |
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
LHGDN |
Changes of NF-kB, p53, Bcl-2 and caspase in apoptosis induced by JTE-522 in human gastric adenocarcinoma cell line AGS cells: role of reactive oxygen species.
|
12046064 |
2002 |
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We comparatively assessed 41 mucinous colorectal carcinomas (MUCs) and 620 non-MUC (well-, moderately, and poorly differentiated adenocarcinoma) cases for clinicopathologic findings; and 41 MUCs and 115 randomly selected non-MUCs also were studied for the following: (1) apoptotic activity and Ki-67 immunoreactivity; (2) immunohistochemical expression of p21(WAF1/CIP1), p27Kip1, p53, and bcl-2; and (3) c-Ki-ras mutations.
|
12047142 |
2002 |