REN, renin, 5972

N. diseases: 721; N. variants: 25
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001969
Disease: Alcoholic Intoxication
Alcoholic Intoxication
0.300 Biomarker disease PSYGENET Antisense significantly reduced (by about 50%) the volume of water drunk in response to intracerebroventricular (icv) renin or isoproterenol but did not reduce drinking in response to the physiological challenge of icv angiotensin II, icv carbachol, intravenous hypertonic saline, water deprivation or subcutaneous injection of polyethylene glycol. 9247770 1997
CUI: C0001969
Disease: Alcoholic Intoxication
Alcoholic Intoxication
0.300 Biomarker disease PSYGENET Antisense treatment significantly reduced (by approximately 50%) the volume of water drunk in response to i.c.v. injection of renin or subcutaneous isoproterenol, but did not reduce water intake elicited by the other dipsogenic stimuli.The i.c.v. administration of mismatch, scrambled or sense oligonucleotides did not inhibit water intake. 9406916 1997