Anemia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
DKD-related anemia developed earlier and was more severe than non-DKD-related anemia based on more complicated mechanisms, including greater bleeding tendency associated with antiplatelet effect, less O2 sensing due to autonomic neuropathy or renin-angiotensin-aldosterone system inhibitor use, inhibitory effect of inflammatory cytokines, urinary loss of erythropoietin (EPO), and poor response to EPO.
|
31453863 |
2019 |
Anemia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These factors include: (1) activation of the renin-angiotensin-aldosterone system, (2) anemia, (3) hypercalcemia, hyperphosphatemia and increased levels of FGF-23, and (4) uremic toxins.
|
31551803 |
2019 |
Anemia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Inhibition of the renin-angiotensin system in the cardiorenal syndrome with anaemia: a double-edged sword.
|
31490340 |
2019 |
Anemia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Heterozygous mutations in the gene encoding renin (REN) cause autosomal dominant tubulointerstitial kidney disease (ADTKD), early-onset anaemia and hyperuricaemia; only four different mutations have been described in the published literature to date.
|
28701203 |
2017 |
Anemia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In multivariate analysis, in the non-extremely elderly group, age (HR 1.027, P < 0.001), body mass index (HR 0.919, P < 0.001), New York Heart Association III or IV (HR 3.626, P < 0.001), preserved ejection fraction (HR 0.553, P < 0.001), anemia (HR 1.941, P < 0.001), β-blockers (HR 0.695, P = 0.028) and renin-angiotensin system inhibitors (HR 0.603, P = 0.001) were independent predictors for all-cause death.
|
28544166 |
2017 |
Anemia
|
0.500 |
Biomarker
|
disease |
BEFREE |
ADKTKD-REN is associated with signs of hyporeninemia: mild hypotension, mild hyperkalemia, anemia in childhood, and hyperuricemia and gout in the teenage years.
|
28284384 |
2017 |
Anemia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A similar clinical syndrome causing the autosomal dominant inheritance of chronic kidney disease, hyperuricemia, and anemia has recently been attributed to mutations in the REN gene encoding renin.
|
21071970 |
2011 |
Anemia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Within the kindred, we found affected individuals over 4 generations who carried the novel REN mutation and were characterized by significant anemia, hyperuricemia, and CKD.
|
21903317 |
2011 |
Anemia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Patients with mutations in the REN gene encoding renin suffer from anemia in childhood, hyperuricemia, mild hyperkalemia, and progressive kidney disease.
|
20807609 |
2010 |
Anemia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A novel REN gene mutation resulted in an alteration in the amino acid sequence of the renin signal sequence and caused childhood anemia, polyuria, and kidney disease.
|
21084044 |
2010 |
Anemia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to determine possible mechanisms linking anemia to renin-angiotensin system activity in CHF patients.
|
16172283 |
2005 |
Anemia
|
0.500 |
Biomarker
|
disease |
CTD_human |
Participation of the renin-angiotensin system in the captopril-induced worsening of anemia in chronic hemodialysis patients.
|
3524928 |
1986 |
Anemia
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|