REN, renin, 5972

N. diseases: 721; N. variants: 25
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation disease BEFREE DKD-related anemia developed earlier and was more severe than non-DKD-related anemia based on more complicated mechanisms, including greater bleeding tendency associated with antiplatelet effect, less O2 sensing due to autonomic neuropathy or renin-angiotensin-aldosterone system inhibitor use, inhibitory effect of inflammatory cytokines, urinary loss of erythropoietin (EPO), and poor response to EPO. 31453863 2019
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation disease BEFREE These factors include: (1) activation of the renin-angiotensin-aldosterone system, (2) anemia, (3) hypercalcemia, hyperphosphatemia and increased levels of FGF-23, and (4) uremic toxins. 31551803 2019
CUI: C0002871
Disease: Anemia
Anemia
0.500 Biomarker disease BEFREE Inhibition of the renin-angiotensin system in the cardiorenal syndrome with anaemia: a double-edged sword. 31490340 2019
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation disease BEFREE Heterozygous mutations in the gene encoding renin (REN) cause autosomal dominant tubulointerstitial kidney disease (ADTKD), early-onset anaemia and hyperuricaemia; only four different mutations have been described in the published literature to date. 28701203 2017
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation disease BEFREE In multivariate analysis, in the non-extremely elderly group, age (HR 1.027, P < 0.001), body mass index (HR 0.919, P < 0.001), New York Heart Association III or IV (HR 3.626, P < 0.001), preserved ejection fraction (HR 0.553, P < 0.001), anemia (HR 1.941, P < 0.001), β-blockers (HR 0.695, P = 0.028) and renin-angiotensin system inhibitors (HR 0.603, P = 0.001) were independent predictors for all-cause death. 28544166 2017
CUI: C0002871
Disease: Anemia
Anemia
0.500 Biomarker disease BEFREE ADKTKD-REN is associated with signs of hyporeninemia: mild hypotension, mild hyperkalemia, anemia in childhood, and hyperuricemia and gout in the teenage years. 28284384 2017
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation disease BEFREE A similar clinical syndrome causing the autosomal dominant inheritance of chronic kidney disease, hyperuricemia, and anemia has recently been attributed to mutations in the REN gene encoding renin. 21071970 2011
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation disease BEFREE Within the kindred, we found affected individuals over 4 generations who carried the novel REN mutation and were characterized by significant anemia, hyperuricemia, and CKD. 21903317 2011
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation disease BEFREE Patients with mutations in the REN gene encoding renin suffer from anemia in childhood, hyperuricemia, mild hyperkalemia, and progressive kidney disease. 20807609 2010
CUI: C0002871
Disease: Anemia
Anemia
0.500 GeneticVariation disease BEFREE A novel REN gene mutation resulted in an alteration in the amino acid sequence of the renin signal sequence and caused childhood anemia, polyuria, and kidney disease. 21084044 2010
CUI: C0002871
Disease: Anemia
Anemia
0.500 AlteredExpression disease BEFREE The aim of the present study was to determine possible mechanisms linking anemia to renin-angiotensin system activity in CHF patients. 16172283 2005
CUI: C0002871
Disease: Anemia
Anemia
0.500 Biomarker disease CTD_human Participation of the renin-angiotensin system in the captopril-induced worsening of anemia in chronic hemodialysis patients. 3524928 1986
CUI: C0002871
Disease: Anemia
Anemia
0.500 Biomarker disease HPO