REN, renin, 5972

N. diseases: 721; N. variants: 25
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 AlteredExpression disease BEFREE Brain insulin signaling is accounted for the development of a variety of neuropsychiatric disorders, such as anxiety and depression, whereas both inflammation and the activated renin-angiotensin system (RAS) are two major contributors to insulin resistance. 31001119 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 AlteredExpression disease BEFREE Decreased level of BDNF is observed in depression and its connection to hypertension has also been demonstrated with affecting the arterial baroreceptors, renin-angiotensin system and endothelial nitric oxide synthase. 30767081 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease BEFREE The results revealed that HO-1 and renin precursor (Rep) were independent factors that affected hypertension complicated with depression. 31410134 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease BEFREE These findings emphasize the potential impact of depression on the low renin-hypertension phenotype in Blacks in terms of diagnosis and treatment. 29960014 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease BEFREE Drugs targeting the renin-angiotensin system act on inflammatory pathways implicated in depression. 28760142 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease BEFREE The importance of renin-angiotensin system (RAS) elements in cognition and behaviour and their involvement in aetiology and treatment of depression imply that RAS gene polymorphism(s) associated with RAS overactivity might also be associated with depression. 22688325 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease PSYGENET The importance of renin-angiotensin system (RAS) elements in cognition and behaviour and their involvement in aetiology and treatment of depression imply that RAS gene polymorphism(s) associated with RAS overactivity might also be associated with depression. 22688325 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 GeneticVariation disease BEFREE Four single nucleotide polymorphisms in the central serotonin system and the renin-angiotensin system related genes previously found to be associated with suicide, alcohol dependence or depression were genotyped. 19734157 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease PSYGENET Four single nucleotide polymorphisms in the central serotonin system and the renin-angiotensin system related genes previously found to be associated with suicide, alcohol dependence or depression were genotyped. 19734157 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease PSYGENET Renin-angiotensin-system gene polymorphisms and depression. 17499413 2007
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease PSYGENET Regarding the multiple interactions in the mechanisms between depression and cardiovascular system disorders, e.g., dysfunctions in the hypothalamic-pituitary-adrenocortical and sympathoadrenal axis and the response to stress, the importance of the serotonergic and immune systems, or the impact on the renin-angiotensin system, several candidate genes are being investigated. 17506223 2007
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 GeneticVariation disease BEFREE Renin-angiotensin-system gene polymorphisms and depression. 17499413 2007
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease BEFREE Regarding the multiple interactions in the mechanisms between depression and cardiovascular system disorders, e.g., dysfunctions in the hypothalamic-pituitary-adrenocortical and sympathoadrenal axis and the response to stress, the importance of the serotonergic and immune systems, or the impact on the renin-angiotensin system, several candidate genes are being investigated. 17506223 2007
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.390 Biomarker disease PSYGENET These results suggest that blockade of the renin-angiotensin system may increase the abundance of mRNA for SR proteins and, thus, may prevent the depression in SR Ca(2+) transport and improve cardiac function in congestive heart failure due to MI. 15576437 2005