Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE Discovery of a novel dominant mutation in the REN gene after forty years of renal disease: a case report. 28701203 2018
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 AlteredExpression group BEFREE The presence of local renin angiotensin aldosterone systems (RAAS) in the cardiovascular and renal tissues and their influence in cardiovascular and renal diseases are described. 27884223 2017
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 Biomarker group BEFREE The enzyme renin plays a key role in the RAAS cascade and an important role in the development of hypertension and progression of renal disease in ADPKD. 26753721 2016
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 Biomarker group BEFREE Our data suggest the application of a renin inhibitor for preventing kidney disease progression in CKD patients. 24154707 2016
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE The influence of renin-angiotensin system genotypes on the antiproteinuric response to high doses of olmesartan in non-diabetic proteinuric nephropathies. 24241364 2015
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE These include: (1) the intra-renal renin-angiotensin system (RAS), one based on molecular variations in angiotensinogen; (2) the Na, K, 2Cl cotransporter (NKCC2) and its regulators in the thick ascending limb, which are associated with a variety of phenotypes consistent with a more active cotransporter in blacks; and (3) the genes for MYH9 and APOL 1, which have been associated with kidney disease in blacks. 23397215 2013
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 Biomarker group BEFREE The objective of this study was dual: to investigate whether mice overexpressing renin could mimic the kinetics and the physiopathological characteristics of hypertension-induced renal disease and to identify cellular and/or molecular events characterizing the different steps of the progression of CKD. 23300650 2013
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE Renin-angiotensin-aldosterone system genotypes and haplotypes affect the susceptibility to nephropathy in type 2 diabetes patients. 21421655 2012
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 AlteredExpression group BEFREE In animal models for human FSGS (doxorubicin nephropathy) and increased renin-angiotensin system activity (Ren2 transgenic rats), glomerular TRPC6 expression was increased in an AngII-dependent manner. 21839714 2012
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE A novel REN gene mutation resulted in an alteration in the amino acid sequence of the renin signal sequence and caused childhood anemia, polyuria, and kidney disease. 21084044 2011
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE Renoprotective efficacy of valsartan in chronic non-diabetic proteinuric nephropathies with renin-angiotensin system gene polymorphisms. 21303424 2011
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 Biomarker group BEFREE This indicates a protective role for catalase and underscores the importance of the intrarenal renin-angiotensin system in renal disease. 20508664 2010
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 AlteredExpression group BEFREE This paper will review the experimental and clinical evidence on the use of GAGs in renal disease other than diabetic nephropathy, following the reports of experimental findings supporting their use and the possible mechanisms involved: anticoagulant and antiproliferative activity, effect on growth factors (PDGF, FGF2 and TGF-beta1), inhibition of heparanase, macrophage renal infiltration and of the renin-angiotensin system, and decrease in proteinuria. 20155726 2010
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease. 19290794 2009
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE Clinical and experimental studies that discuss the different immune functions of the renin-angiotensin system (RAS) in kidney diseases were reviewed, with emphasis on studies of kidney transplantation. 19539879 2009
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE Controlling hypertension by angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB), mechanisms that inhibit later pathway steps in the renin-angiotensin system (RAS), have clinically afforded protection against cardiac and renal disease. 18679781 2009
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE We speculate that presymptomatic patients with normal renal function who have genetic or familial FSGS may benefit from early blockade of the renin-angiotensin axis and that this may also prevent progressive renal disease. 17530296 2008
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE These data confirm the key role of the renin-angiotensin system to maintain glomerular filtration rate, and highlight an association between a genetic factor and susceptibility to and prognosis of acute kidney disease. 19020433 2008
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE Angiotensin II, the most vasoactive component of the renin-angiotensin-aldosterone (RAAS) pathway, can contribute to renal disease by causing an increase in arterial blood pressure leading to glomerular injury and fibrosis. 18206321 2008
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE We examined an association of the three renin-angiotensin system (RAS) gene polymorphisms with renal disease and progression to ESRD in dialyzed patients. 16384824 2006
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE The renin-angiotensin system (RAS) is implicated in various immunological and non-immunological phenomena, and the polymorphism of the RAS genes has been associated with cardiovascular and renal disease onset and outcome. 16047641 2005
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE Genetic polymorphisms of the renin-angiotensin system (RAS) have been implicated in the pathogenesis of nephropathy and end-stage renal disease (ESRD). 15012717 2004
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 AlteredExpression group BEFREE The activity of the renin-angiotensin-aldosterone system (RAAS) is elevated both in the circulation and in the renal tissue of diabetic and nondiabetic nephropathies. 15017527 2004
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 Biomarker group BEFREE Genotypes of the renin-angiotensin system have been implicated in essential hypertension and in progression of native kidney diseases, but gene effects on progression in chronic renal allograft dysfunction are unclear. 12548125 2003
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.400 GeneticVariation group BEFREE Relationship between polymorphisms in the renin-angiotensin system and nephropathy in type 2 diabetic patients. 11938025 2002