REN, renin, 5972

N. diseases: 721; N. variants: 25
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 Biomarker disease BEFREE The renin-angiotensin-aldosterone system and its hormone receptors, i.e. the angiotensin and mineralocorticoid receptor (MR), have emerged as important targets for central nervous system disorders and in particular for major depression. 30300165 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 Biomarker disease BEFREE Extensive distribution of the different components of renin angiotensin system (RAS) in the brain, along with their roles in promoting anxiety, depression and brain inflammation, opposes RAS as a potential therapeutic target in major depression. 27262302 2016
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 Biomarker disease PSYGENET Association of angiotensin-converting enzyme (ACE) gene polymorphism with elevated serum ACE activity and major depression in an Iranian population. 22688325 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 Biomarker disease PSYGENET Clinical and genetic risk factors for suicide under the influence of alcohol in a Polish sample. 19734157 2010
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 Biomarker disease PSYGENET The major findings regarding the genetics of stress response and stress-related disorders are: (i) variations in genes involved in the sympathetic system or in the hypothalamic-pituitary-adrenocortical axis are associated with altered stress responses; (ii) genes related to the renin-angiotensin-aldosterone system or inflammation/immune response show associations with cardiovascular disorders; (iii) genes involved in monoaminergic neurotransmitter systems are associated with bipolar disorder and unipolar depression. 17290801 2006
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 Biomarker disease BEFREE The major findings regarding the genetics of stress response and stress-related disorders are: (i) variations in genes involved in the sympathetic system or in the hypothalamic-pituitary-adrenocortical axis are associated with altered stress responses; (ii) genes related to the renin-angiotensin-aldosterone system or inflammation/immune response show associations with cardiovascular disorders; (iii) genes involved in monoaminergic neurotransmitter systems are associated with bipolar disorder and unipolar depression. 17290801 2006