REN, renin, 5972

N. diseases: 721; N. variants: 25
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.100 Biomarker phenotype BEFREE Brain renin-angiotensin system hyperactivity has been implicated in the development and maintenance of hypertension. 31067198 2019
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.100 Biomarker phenotype BEFREE Brain renin-angiotensin system (RAS) hyperactivity has been implicated in the development and maintenance of hypertension. 31115779 2019
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.100 AlteredExpression phenotype BEFREE The sympathetic nervous system (SNS) and renin-angiotensin-aldosterone system (RAAS) become activated to maintain cardiac output; however, their chronic hyperactivity will eventually become deleterious. 30553703 2019
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.100 Biomarker phenotype BEFREE The model used to explain the pathophysiologic substrate and progressive worsening in chronic heart failure (CHF) is based on the hyperactivity of renin-angiotensin-aldosterone system and adrenergic pathway. 31079695 2019
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.100 Biomarker phenotype BEFREE Brain renin-angiotensin system (RAS) hyperactivity has been implicated in sympathetic hyperactivity and progressive left ventricular (LV) dysfunction after myocardial infarction (MI). 30599150 2019
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.100 Biomarker phenotype BEFREE Hyperactivity of the brain renin-angiotensin (Ang) system has been implicated in the development and maintenance of hypertension. 28968260 2018
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.100 Biomarker phenotype BEFREE Kallikrein-kinin system as the dominant mechanism to counteract hyperactive renin-angiotensin system. 28384411 2017
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.100 Biomarker phenotype BEFREE In the development of RHT, hyperactivity of sympathetic (SNS) and renin-angiotensin-aldosterone (SRAA) systems are involved, and SNS is a potent stimulator of vasoactive endothelin-1 (ET-1) peptide. 28084122 2017
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.100 Biomarker phenotype BEFREE Hyperactivity of the renin-angiotensin system (RAS) is associated with the pathogenesis of Alzheimer's disease (AD) believed to be mediated by angiotensin-II (Ang-II) activation of the angiotensin type 1 receptor (AT1R). 28387670 2017
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.100 GeneticVariation phenotype BEFREE Hyperactivity of the classical axis of the renin-angiotensin system (RAS), mediated by angiotensin II (Ang II) activation of the angiotensin II type 1 receptor (AT1R), is implicated in the pathogenesis of Alzheimer's disease (AD). 27884212 2016
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.100 Biomarker phenotype BEFREE Hyperactivity of the renin-angiotensin system (RAS) resulting in elevated Angiotensin II (Ang II) contributes to all stages of inflammatory responses including ocular inflammation. 25228068 2014
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior
0.100 Biomarker phenotype BEFREE In this pathologic scenario, there is a renin-angiotensin system (RAS) hyperactivity associated to progression of renal damage. 23079502 2012