|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Upregulation of SNHG6 expression induced RKO and HCT116 cell proliferation as well as RKO cell metastasis, while downregulation of SNHG6 expression supressed the proliferation and metastasis of RKO cells and tumor growth <i>in vivo.</i> UPF1 was upregulated and ZEB1 was decreased when SNHG6 knockdown, regulating the TGF-β/Smad pathway and inducing EMT respectively.
|
30662328 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
In the present study, the role of Up‑frameshift 1 (UPF1), a potential tumor suppressor, was investigated in the HCC cell lines.
|
30628676 |
2019 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
A lower level of UPF1 was observed in glioma tissues in the more advanced stage with a larger tumor size.
|
31799670 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Collectively, UPF1 functions as a tumor suppressor by preventing cancer stem cell (CSC)-like characteristics, inhibiting EMT process and enhancing chemotherapeutic sensitivity via inhibiting ABCC2 expression in HCC cells.
|
28554132 |
2017 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Our findings revealed that UPF1 is a potential tumor suppressive gene and may be a potential therapeutic target for HCC.
|
26759305 |
2016 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Additionally, the predominant nuclear localization of UPF1 in normal glandular cells and low grade tumors was switched to a more cytoplasmic pattern in carcinomas with Gleason score >7.
|
23881279 |
2013 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
A negative effect of UPF1 and UPF2 expression on the host's anti-tumor response was observed (P<0.01).
|
18612427 |
2008 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
We show that NMD is responsible for this robust downregulation, as CDH1 transcripts harbouring PTCs in the KATO-III gastric tumour cell line were upregulated in response to protein synthesis inhibitors or depletion of the NMD factors UPF1 and eIF4AIII.
|
18427545 |
2008 |
|
Liver carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
The results of the present study revealed that UPF1 was significantly downregulated in an HCC cell line.
|
30628676 |
2019 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Knockdown of UCA1 ameliorated the effect of UPF1 knock down on HCC growth and invasion.
|
31040354 |
2019 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings showed that SNAI3-AS1 promotes the progression of HCC by regulating the UPF1 and activating TGF-β/Smad pathway.
|
31264769 |
2019 |
|
Liver carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
In clinical samples of HCC, miR-1468 inversely correlated with the levels of CITED2 and UPF1, which were confirmed to be down-regulated in HCC.
|
29510736 |
2018 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
These findings establish UPF1 as a potential therapeutic target for HCC patients.
|
28554132 |
2017 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Functionally, UPF1 regulated HCC tumorigenesis both in vitro and in vivo.
|
26759305 |
2016 |
|
Liver carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Upregulation of SNHG6 regulates ZEB1 expression by competitively binding miR-101-3p and interacting with UPF1 in hepatocellular carcinoma.
|
27702662 |
2016 |
|
Malignant Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
In silico screening of UPF1 stability change as a function over 41 cancer mutations has identified five variants with significant effects: K164R, R253W, T499M, E637K, and E833K.
|
31718065 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Our results reveal that Linc-ASEN prevents cellular senescence by reducing the transcription and stability of p21 mRNA in concert with UPF1, and suggest that Linc-ASEN might be a potential therapeutic target in processes influenced by senescence, including cancer.
|
31819156 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
In silico screening of UPF1 stability change as a function over 41 cancer mutations has identified five variants with significant effects: K164R, R253W, T499M, E637K, and E833K.
|
31718065 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Our results reveal that Linc-ASEN prevents cellular senescence by reducing the transcription and stability of p21 mRNA in concert with UPF1, and suggest that Linc-ASEN might be a potential therapeutic target in processes influenced by senescence, including cancer.
|
31819156 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Collectively, UPF1 functions as a tumor suppressor by preventing cancer stem cell (CSC)-like characteristics, inhibiting EMT process and enhancing chemotherapeutic sensitivity via inhibiting ABCC2 expression in HCC cells.
|
28554132 |
2017 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Collectively, UPF1 functions as a tumor suppressor by preventing cancer stem cell (CSC)-like characteristics, inhibiting EMT process and enhancing chemotherapeutic sensitivity via inhibiting ABCC2 expression in HCC cells.
|
28554132 |
2017 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Collectively, PKP1/3-associated RBPs FXR1 and UPF1 may have a functional role in prostate cancer progression and metastasis and highlight the potential importance of posttranscriptional regulation of gene expression and nonsense-mediated decay in cancer.
|
23881279 |
2013 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Collectively, PKP1/3-associated RBPs FXR1 and UPF1 may have a functional role in prostate cancer progression and metastasis and highlight the potential importance of posttranscriptional regulation of gene expression and nonsense-mediated decay in cancer.
|
23881279 |
2013 |
|
Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The study is the first to prove that the UPF1-Linc-00313-miR-342-3p/miR-485-5p-Zic4-SHCBP1 pathway forms a positive-feedback loop and regulates the biological behaviors of U87 and U251 cells, which might provide a new therapeutic target for glioma.
|
31427569 |
2019 |
|
Glioma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
UPF1 was conversely downregulated in glioma patients.
|
31696483 |
2019 |