RET, ret proto-oncogene, 5979

N. diseases: 607; N. variants: 162
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.400 AlteredExpression disease BEFREE Changes in RET expression have been discovered in 30-70% of invasive breast cancers and 50-60% of pancreatic ductal adenocarcinomas in addition to colorectal adenocarcinoma, melanoma, small cell lung cancer, neuroblastoma, and small intestine neuroendocrine tumors. 31715421 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Our data unveiled a new mechanism of alleviating IFNγ-induced PD-L1 and IDO1 expression and provided a rationale to explore a novel combination of ICB with regorafenib clinically, especially in melanoma with RET/Src axis activation. 30940655 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Tumor therapy experiments were performed using syngeneic mouse tumor cells (RET melanoma and Panc02 pancreatic adenocarcinoma) transduced with human L1CAM. 25230579 2015
CUI: C0025202
Disease: melanoma
melanoma 		0.400 GeneticVariation disease BEFREE The RET G691S polymorphism was found in 25% of pure and 38% of mixed desmoplastic melanomas. 25769001 2015
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Here we showed that levels of Dtx3l/DTX3L in spontaneous melanoma in RFP/RET-transgenic mice and human melanoma cell lines were significantly higher than those in benign melanocytic cells and primarily cultured normal human epithelial melanocytes, respectively. 26033450 2015
CUI: C0025202
Disease: melanoma
melanoma 		0.400 GeneticVariation disease BEFREE BRAF(V600E) allele was detected in PTC and melanoma but not in MTC tissues. 24858900 2014
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE The present study evaluates the impact of immune cell populations on metastatic development in a model of spontaneous melanoma [mice expressing the human RET oncogene under the control of the metallothionein promoter (MT/ret mice)]. 23878221 2013
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Furthermore, they prevent metastasis in a RET transgenic mice model which develops melanoma. 23109338 2012
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Taken together with the finding of augmented proliferation of HM3KO cells after GDNF stimulation, our results suggest that GDNF-mediated c-RET kinase activation is associated with the pathogenesis of malignant melanoma. 20422010 2010
CUI: C0025202
Disease: melanoma
melanoma 		0.400 Biomarker disease BEFREE Moreover, HB-19 treatment caused selective down regulation of transcripts coding matrix metalloproteinase 2 and 9, and tumor necrosis factor-alpha in the TIII cells and in melanoma tumors of RET mice. 20573279 2010
CUI: C0025202
Disease: melanoma
melanoma 		0.400 GeneticVariation disease BEFREE Activating mutations of RET were previously reported in several types of cancer, including thyroid, pituitary, adrenal and melanoma cancer. 20201982 2010
CUI: C0025202
Disease: melanoma
melanoma 		0.400 CausalMutation disease CGI