RFC1, replication factor C subunit 1, 5981

N. diseases: 144; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.070 GeneticVariation disease BEFREE Our data suggest that TS2R/2R and 3R/3R or MTHFR CT genotypes have a potential role in identifying patients with greater risk of toxicity to CMF/FEC and that RFC1 GG and GSTT1-null genotypes alone or in combination could be important markers in predicting clinical outcome in EBC patients. 28747156 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.070 GeneticVariation disease BEFREE RFC1 rs6829064 (AA) was associated with an increased BC risk [OR = 1.35; 95% confidence interval (CI) = 1.06-1.73] compared to the wild genotype (GG). 28940489 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.070 GeneticVariation disease BEFREE Cross-talk was observed between one-carbon and xenobiotic pathways in breast cancer (RFC 80 G>A, COMT H108L and TYMS 5'-UTR 28 bp tandem repeat) and SLE (CYP1A1 m1, MTRR 66 A>G and GSTT1). 25648260 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.070 GeneticVariation disease BEFREE Conversely, for women over 50, the risk of breast cancer development was statistically associated with the MTHFR 677CT genotype, but especially significant was risk associated with the presence of the polymorphic allele of cSHMT C1420T (P = 0.0120) and the protective effect associated with the RFC1 G80A polymorphism allele (P = 0.0021), was restrict to this age group. 22134752 2012
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.070 GeneticVariation disease BEFREE MDR analysis demonstrated a significant tri-variate interaction among RFC1 80, MTHFR 677 and TYMS 5'-UTR loci (P (trend) < 0.02) with high-risk genotype combination showing inflated risk for breast cancer (OR 4.65, 95% CI 1.77-12.24). 21161404 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.070 GeneticVariation disease BEFREE We observed no association between the MTHFR, RFC, MS and MTRR genotypes and the risk of breast cancer. 18204969 2008
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.070 GeneticVariation disease BEFREE Genetic polymorphisms of glutathione S-transferase (GST) genes including GSTT1 positive/null, GSTM1 positive/null, and GSTP1 A313G, and genes for reduced folate carrier 1 G80A (RFC1 G80A), methylenetetrahydrofolate reductase C677T (MTHFR C677T), and breast cancer resistant protein C421A (BCRP C421A) were determined for 26 patients by the polymerase chain reaction (PCR) method or by direct sequencing. 17180579 2007