|
Crohn Disease
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
We identify BACH2 as a susceptibility locus for postoperative recurrence of Crohn's disease in our cohort.
|
29452228 |
2018 |
|
Crohn Disease
|
0.440 |
AlteredExpression
|
disease |
BEFREE |
We identified a transcription-factor network, including BACH2, RORγt, FOSL2, AP-1 and RUNX1, that controlled expression of the wound-healing program, and found a CD161<sup>+</sup> T<sub>reg</sub> cell signature in Crohn's disease mucosa associated with reduced inflammation.
|
30397350 |
2018 |
|
Crohn Disease
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
Crohn Disease
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Crohn Disease
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Crohn Disease
|
0.440 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms within a single locus encoding the transcription factor BACH2 are associated with numerous autoimmune and allergic diseases including asthma, Crohn's disease, coeliac disease, vitiligo, multiple sclerosis and type 1 diabetes.
|
23728300 |
2013 |
|
Crohn Disease
|
0.440 |
Biomarker
|
disease |
BEFREE |
We observe a significant boost in the power to detect validated candidate genes for Crohn's disease and type 2 diabetes by comparing our predictions to results from follow-up meta-analyses, with incorporation of the network serving to highlight the JAK-STAT pathway and associated adaptors GRB2/SHC1 in Crohn's disease and BACH2 in type 2 diabetes.
|
21536720 |
2011 |
|
Crohn Disease
|
0.440 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
Crohn Disease
|
0.440 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
Crohn Disease
|
0.440 |
Biomarker
|
disease |
CTD_human |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
Initial results showed modest methylation differences between discordant MZ twins for the MHC region and T1D-associated CpG sites, BACH2, INS-IGF2, and CLEC16A (DNAm difference range: 2.2%-5.0%).
|
26782299 |
2016 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.430 |
GeneticVariation
|
disease |
GWASCAT |
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
|
25751624 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.430 |
Biomarker
|
disease |
BEFREE |
The present findings suggest that the type 1 diabetes candidate gene BACH2 regulates proinflammatory cytokine-induced apoptotic pathways in pancreatic β-cells by crosstalk with another candidate gene, PTPN2, and activation of JNK1 and BIM.
|
24608439 |
2014 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms within a single locus encoding the transcription factor BACH2 are associated with numerous autoimmune and allergic diseases including asthma, Crohn's disease, coeliac disease, vitiligo, multiple sclerosis and type 1 diabetes.
|
23728300 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.430 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
|
21829393 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.430 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
|
21980299 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.430 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.430 |
GeneticVariation
|
disease |
GWASCAT |
Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.
|
18840781 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.430 |
GeneticVariation
|
disease |
GWASDB |
Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.
|
18840781 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.430 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.430 |
Biomarker
|
disease |
CTD_human |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.430 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.430 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
|
18978792 |
2008 |
|
Celiac Disease
|
0.420 |
Biomarker
|
disease |
BEFREE |
Finally, ZFP36L1, ZMIZ1, PUS10, UBE2L3, and BACH2 showed opposite results in CeD and UC.
|
30402962 |
2019 |
|
Celiac Disease
|
0.420 |
GeneticVariation
|
disease |
GWASCAT |
Functional implications of disease-specific variants in loci jointly associated with coeliac disease and rheumatoid arthritis.
|
26546613 |
2016 |