PAPPA2, pappalysin 2, 60676

N. diseases: 28; N. variants: 13
Disease: Eclampsia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0013537
Disease: Eclampsia
Eclampsia 		0.020 AlteredExpression disease BEFREE There is some evidence that PAPPA2 mRNA and protein are increased in association with pre-eclampsia. 23484525 2014
CUI: C0013537
Disease: Eclampsia
Eclampsia 		0.020 AlteredExpression disease BEFREE Maternal serum concentrations of PAPP-A2 but not PAPP-A were also significantly elevated in pre-eclampsia as compared with uncomplicated pregnancy. mRNA levels of IGFBP5, a specific substrate for PAPP-A2 protease activity, were also significantly increased, suggesting a potential role for IGFBP5 in fetal and placental growth suppression during pre-eclampsia. 18805800 2008