Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Neurotrophins such as brain-derived neurotrophic factor (BDNF), inflammation and oxidative damage may contribute to the pathophysiology of bipolar disorder (BD) in terms of illness activity.
|
30808582 |
2019 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of 19 candidate genes in peripheral blood, plasma levels of BDNF, NT-3, IL-6 and IL-18, leukocyte counts, and urinary markers of oxidative damage to DNA and RNA were measured in 37 adult rapid-cycling patients with BD in different affective states during a 6- to 12-month period and in 40 age- and gender-matched healthy individuals in a longitudinal, repeated measures design comprising a total of 211 samples.
|
30383306 |
2019 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, there were trends toward correlations between BDNF expression and disease duration in BD group and between BDNF expression and age in health subjects (P values = 0.05).
|
30979423 |
2019 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Further and larger genetic studies are required in order to detect association between BDNF polymorphism, BDNF levels, brain abnormalities and cognition in BD.
|
30078664 |
2019 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The results of this study suggest that FR has no effect on peripheral BDNF levels in euthymic patients with BD, despite the improvement in psychosocial functioning.
|
31076186 |
2019 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Brain-derived neurotrophic factor (BDNF) and bipolar disorder.
|
30852433 |
2019 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
A clear selective role of DNA methylation involvement in BD-II is shown here, further supporting a role for BDNF and its possible interaction with PDYN.
|
28830794 |
2018 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together with the fact that EGR3 regulates the expression of the neurotrophin receptor p75NTR and may also indirectly induce BDNF expression, here we propose a feed-forward gene regulatory network involving EGR3 and BDNF and its potential role in BD.
|
29459824 |
2018 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
We investigated whether add-on memantine to regular valproic acid treatment ameliorated clinical symptoms, reduced alcohol use, and cytokine levels, and increased plasma brain-derived neurotrophic factor (BDNF) in BD-II patients with comorbid alcohol dependence.
|
29656414 |
2018 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Sigma-1 receptor can modulate a number of central neurotransmitter systems as well as some other signaling pathways (e.g., neurotrophin and growth factor signaling) which are seemingly involved in BD and other mood disorders.
|
28144920 |
2017 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our previous work provided suggestive evidence for brain-derived neurotrophic factor (BDNF) in differentiating BD from MDD.
|
27613282 |
2017 |
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach.Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers.
|
28479278 |
2017 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Serum BDNF levels may not indicate high genetic risk for BD, possibly acting as state markers rather than trait markers of the disease.
|
26870912 |
2017 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to examine potential differences in brain-derived neurotrophic factor, cytokines, oxidative stress, and telomere length markers between patients with bipolar disorder, their siblings, and healthy controls.
|
28339618 |
2017 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Brain-derived neurotrophic factor (BDNF) is proposed as a neurotrophic marker in BD.
|
28711724 |
2017 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Offspring status and BMI moderate the association between BDNF levels and brain structures among bipolar offspring, underscoring BDNF regulation and overweight/obesity as key moderators of BD pathogenesis.
|
29023633 |
2017 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The concentration of BDNF in body fluid is highly related to several neurodevelopmental and psychiatric diseases, including Alzheimer's diseases, depression, schizophrenia, and bipolar disorder.
|
28215308 |
2017 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In high BDNF BD subjects, LPH was significantly positively correlated with IED completed stage trials (ρ = 0.755, p = 0.001) and pre-extra-dimensional shift errors (ρ = 0.588, p = 0.017).Correlations were opposite in controls.
|
27957714 |
2017 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In particular peripheral brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker related to disease activity and neuroprogression in BD.
|
27837670 |
2017 |
Bipolar Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Brain-derived neurotrophic factor (BDNF) and inflammatory markers are leading biomarkers in BD.
|
28199074 |
2017 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The levels of mature BDNF in the parietal cortex from MDD, SZ and BD groups were significantly lower than the control group, whereas the levels of BDNF pro-peptide in this area were significantly higher than controls.
|
28509900 |
2017 |
Bipolar Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Putatively detrimental effects of childhood trauma exposure on adult BDNF serum levels are influenced by 5-HTTLPR genotype in patients affected by BD.
|
28754344 |
2017 |
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
BDNF rs6265 was associated with St in the BD group (p = 0.017).
|
30041166 |
2017 |
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
BDNF Val66Met polymorphism and bipolar disorder in European populations: A risk association in case-control, family-based and GWAS studies.
|
27236043 |
2016 |
Bipolar Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We aimed to investigate the association of NRN1 with schizophrenia-spectrum disorders (SSD) and bipolar disorders (BPD), to explore its role in age at onset and cognitive functioning, and to test the epistasis between NRN1 and BDNF.
|
26700405 |
2016 |