BDNF, brain derived neurotrophic factor, 627

N. diseases: 992; N. variants: 56
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE Neurotrophins such as brain-derived neurotrophic factor (BDNF), inflammation and oxidative damage may contribute to the pathophysiology of bipolar disorder (BD) in terms of illness activity. 30808582 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 AlteredExpression disease BEFREE Expression levels of 19 candidate genes in peripheral blood, plasma levels of BDNF, NT-3, IL-6 and IL-18, leukocyte counts, and urinary markers of oxidative damage to DNA and RNA were measured in 37 adult rapid-cycling patients with BD in different affective states during a 6- to 12-month period and in 40 age- and gender-matched healthy individuals in a longitudinal, repeated measures design comprising a total of 211 samples. 30383306 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 AlteredExpression disease BEFREE Moreover, there were trends toward correlations between BDNF expression and disease duration in BD group and between BDNF expression and age in health subjects (P values = 0.05). 30979423 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 AlteredExpression disease BEFREE Further and larger genetic studies are required in order to detect association between BDNF polymorphism, BDNF levels, brain abnormalities and cognition in BD. 30078664 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 AlteredExpression disease BEFREE The results of this study suggest that FR has no effect on peripheral BDNF levels in euthymic patients with BD, despite the improvement in psychosocial functioning. 31076186 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE Brain-derived neurotrophic factor (BDNF) and bipolar disorder. 30852433 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE A clear selective role of DNA methylation involvement in BD-II is shown here, further supporting a role for BDNF and its possible interaction with PDYN. 28830794 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE Taken together with the fact that EGR3 regulates the expression of the neurotrophin receptor p75NTR and may also indirectly induce BDNF expression, here we propose a feed-forward gene regulatory network involving EGR3 and BDNF and its potential role in BD. 29459824 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE We investigated whether add-on memantine to regular valproic acid treatment ameliorated clinical symptoms, reduced alcohol use, and cytokine levels, and increased plasma brain-derived neurotrophic factor (BDNF) in BD-II patients with comorbid alcohol dependence. 29656414 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE Sigma-1 receptor can modulate a number of central neurotransmitter systems as well as some other signaling pathways (e.g., neurotrophin and growth factor signaling) which are seemingly involved in BD and other mood disorders. 28144920 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE Our previous work provided suggestive evidence for brain-derived neurotrophic factor (BDNF) in differentiating BD from MDD. 27613282 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach.Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. 28479278 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 AlteredExpression disease BEFREE Serum BDNF levels may not indicate high genetic risk for BD, possibly acting as state markers rather than trait markers of the disease. 26870912 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE The aim of this study was to examine potential differences in brain-derived neurotrophic factor, cytokines, oxidative stress, and telomere length markers between patients with bipolar disorder, their siblings, and healthy controls. 28339618 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE Brain-derived neurotrophic factor (BDNF) is proposed as a neurotrophic marker in BD. 28711724 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE Offspring status and BMI moderate the association between BDNF levels and brain structures among bipolar offspring, underscoring BDNF regulation and overweight/obesity as key moderators of BD pathogenesis. 29023633 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE The concentration of BDNF in body fluid is highly related to several neurodevelopmental and psychiatric diseases, including Alzheimer's diseases, depression, schizophrenia, and bipolar disorder. 28215308 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE In high BDNF BD subjects, LPH was significantly positively correlated with IED completed stage trials (ρ = 0.755, p = 0.001) and pre-extra-dimensional shift errors (ρ = 0.588, p = 0.017).Correlations were opposite in controls. 27957714 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE In particular peripheral brain-derived neurotrophic factor (BDNF) has been proposed as a potential biomarker related to disease activity and neuroprogression in BD. 27837670 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 Biomarker disease BEFREE Brain-derived neurotrophic factor (BDNF) and inflammatory markers are leading biomarkers in BD. 28199074 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 AlteredExpression disease BEFREE The levels of mature BDNF in the parietal cortex from MDD, SZ and BD groups were significantly lower than the control group, whereas the levels of BDNF pro-peptide in this area were significantly higher than controls. 28509900 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 AlteredExpression disease BEFREE Putatively detrimental effects of childhood trauma exposure on adult BDNF serum levels are influenced by 5-HTTLPR genotype in patients affected by BD. 28754344 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE BDNF rs6265 was associated with St in the BD group (p = 0.017). 30041166 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE BDNF Val66Met polymorphism and bipolar disorder in European populations: A risk association in case-control, family-based and GWAS studies. 27236043 2016
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.600 GeneticVariation disease BEFREE We aimed to investigate the association of NRN1 with schizophrenia-spectrum disorders (SSD) and bipolar disorders (BPD), to explore its role in age at onset and cognitive functioning, and to test the epistasis between NRN1 and BDNF. 26700405 2016