BDNF, brain derived neurotrophic factor, 627

N. diseases: 992; N. variants: 56
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 PosttranslationalModification disease BEFREE Multivariable logistic regression analyses determined the association between BDNF methylation and both prevalent and incident dementia. 31839607 2020
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE Downregulation of brain-derived neurotrophic factor (BDNF) and its cognate neurotrophin receptor, TrkB, were observed during the progression of dementia, but whether the Alzheimer's disease (AD) pathological lesions diffuse plaques, (DPs), neuritic plaques (NPs), and neurofibrillary tangles (NFTs) are related to this alteration remains to be clarified. 31349032 2019
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 AlteredExpression disease BEFREE This finding suggests that a significant change in peripheral BDNF levels can only be detected at the late stage of the dementia spectrum. 30634650 2019
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE Taken together, the current literature provides initial evidence that exercise-induced, blood-borne biomolecules, such as BDNF and FNDC5/irisin, may be powerful agents mediating the benefits of exercise on cognitive function and may form the basis for new therapeutic strategies to better prevent and treat dementia. 30802460 2019
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers. 30775992 2019
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE We found that the APOE ε4 allele is associated with a higher risk for PD-D. Gene-gene interaction analysis revealed that three significant gene-gene interactions, including BDNF and CLU, APOE and CR1, and DYRK1A and CD2AP increase the risk for PD. 29698690 2018
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE Sixteen percent of BP patients with the lowest serological BDNF presented dementia-BP clinical association. 30220011 2018
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 AlteredExpression disease BEFREE BDNF levels were lower in the MDD group with dementia than in participants with dementia and without MDD as confirmed by multivariate analysis adjusted for clinical and cardiovascular risk factors (ß = -0.106, 95%CI = -0.204; -0.009, p = 0.034). 30125821 2018
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE Above all, studies suggest that dysbiotic and poorly diversified microbiota may interfere with the synthesis and secretion of neurotrophic factors, such as brain-derived neurotrophic factor, gammaaminobutyric acid and N-methyl D-Aspartate receptors, widely associated with cognitive decline and dementia. 30182854 2018
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 AlteredExpression disease BEFREE The heterogeneity of participant recruitment criteria and the lack of control of variables that influence circulating BDNF levels regardless of dementia (depressive symptoms, medications, lifestyle, lack of overlap between serum and plasma, and experimental aspects) are likely to bias result and prevent study comparability. 29330839 2018
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE Therefore, improving cholinergic neurotransmission, and regulating the BDNF-CREB pathway by downregulating apoptosis genes is one strategy for inhibiting the etiology of dementia. 30018265 2018
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE The present data demonstrated that reduced serum levels of BDNF were associated with increased risk of MCI and might be useful for identifying diabetic patients at risk of dementia for early prevention strategies. 30308512 2018
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 AlteredExpression disease BEFREE Availability of social support appears to be associated with increased BDNF levels and, in certain subsets, reduce risk of subsequent dementia and stroke, thus warranting study of these pathways to understand their role in neuroprotection. 29067329 2017
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE While the exercise-dependent regulation of BDNF is currently undeniable, the role of exercise dependent BDNF as a tool for the improvement of EFs in individuals with dementia is still less clear and seldom discussed. 28469588 2017
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE Increasing levels of S100B, platelet-derived growth factor-AA (PDGF-AA), brain-derived neurotrophic factor (BDNF), and sRAGE were associated with decreased odds of mild neurocognitive disorder (n = 22) or HIV-associated dementia (n = 15) compared with normal function (n = 30) or asymptomatic neurocognitive impairment (n = 11). 27995575 2017
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 AlteredExpression disease BEFREE In the present study, the mRNA and protein expression level of BDNF was detected in serum, and cerebrospinal fluid (CSF) of patients with mild cognitive impairment (MCI), dementia of Alzheimer's type (DAT), and hippocampus in APP/PS1 mice. 27545218 2016
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and post-stroke dementia: a hospital-based study from northern Iran. 27071687 2016
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE The current study examined the association of BDNF genotype and plasma BDNF with hippocampal volume and memory in two large independent cohorts of middle-aged and older adults (both cognitively normal and early-stage dementia).Sample sizes ranged from 123 to 649. 25784293 2015
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE Thus, soluble Aβ42 and BDNF, but not TrkB or soluble tau, correlate with dementia in the oldest-old. 26410307 2015
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 AlteredExpression disease BEFREE Lower BDNF and NGF levels were also observed in the sub-sample of MCI patients who progressed to dementia upon follow-up (p = 0.02 and p = 0.002, respectively). 25737042 2015
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE We used Cox models to relate BDNF levels to the risk for dementia and AD and adjusted for potential confounders. 24276217 2014
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE To investigate the genetic effect of BDNF on cognitive function and regional WMH in the healthy elderly population, 90 elderly men, without dementia, with a mean age of 80.6 ± 5.6 y/o were recruited to undergo cognitive tests, structural magnetic resonance imaging (MRI) scans, and genotyping of BDNF alleles. 24275008 2014
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 Biomarker disease BEFREE As a result, there has been a growing interest in the role of BDNF in neuropsychiatric disorders associated with neurodegeneration, including depression and dementia. 24070857 2013
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE Among 215 outpatients with dementia and MCI, 155 with mild AD (n = 108) or A-MCI (n = 47) were recruited and divided into three genotypic groups based on the representative NT-3 functional polymorphisms rs6332 and rs6489630. 23075484 2012
CUI: C0011265
Disease: Presenile dementia
Presenile dementia
0.400 GeneticVariation disease BEFREE This study investigated modification by BDNF val66met polymorphism of the association between physical activity, incident dementia and other cognitive outcomes. 20172629 2011