Presenile dementia
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Multivariable logistic regression analyses determined the association between BDNF methylation and both prevalent and incident dementia.
|
31839607 |
2020 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Downregulation of brain-derived neurotrophic factor (BDNF) and its cognate neurotrophin receptor, TrkB, were observed during the progression of dementia, but whether the Alzheimer's disease (AD) pathological lesions diffuse plaques, (DPs), neuritic plaques (NPs), and neurofibrillary tangles (NFTs) are related to this alteration remains to be clarified.
|
31349032 |
2019 |
Presenile dementia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This finding suggests that a significant change in peripheral BDNF levels can only be detected at the late stage of the dementia spectrum.
|
30634650 |
2019 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, the current literature provides initial evidence that exercise-induced, blood-borne biomolecules, such as BDNF and FNDC5/irisin, may be powerful agents mediating the benefits of exercise on cognitive function and may form the basis for new therapeutic strategies to better prevent and treat dementia.
|
30802460 |
2019 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers.
|
30775992 |
2019 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found that the APOE ε4 allele is associated with a higher risk for PD-D. Gene-gene interaction analysis revealed that three significant gene-gene interactions, including BDNF and CLU, APOE and CR1, and DYRK1A and CD2AP increase the risk for PD.
|
29698690 |
2018 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Sixteen percent of BP patients with the lowest serological BDNF presented dementia-BP clinical association.
|
30220011 |
2018 |
Presenile dementia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
BDNF levels were lower in the MDD group with dementia than in participants with dementia and without MDD as confirmed by multivariate analysis adjusted for clinical and cardiovascular risk factors (ß = -0.106, 95%CI = -0.204; -0.009, p = 0.034).
|
30125821 |
2018 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Above all, studies suggest that dysbiotic and poorly diversified microbiota may interfere with the synthesis and secretion of neurotrophic factors, such as brain-derived neurotrophic factor, gammaaminobutyric acid and N-methyl D-Aspartate receptors, widely associated with cognitive decline and dementia.
|
30182854 |
2018 |
Presenile dementia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The heterogeneity of participant recruitment criteria and the lack of control of variables that influence circulating BDNF levels regardless of dementia (depressive symptoms, medications, lifestyle, lack of overlap between serum and plasma, and experimental aspects) are likely to bias result and prevent study comparability.
|
29330839 |
2018 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, improving cholinergic neurotransmission, and regulating the BDNF-CREB pathway by downregulating apoptosis genes is one strategy for inhibiting the etiology of dementia.
|
30018265 |
2018 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present data demonstrated that reduced serum levels of BDNF were associated with increased risk of MCI and might be useful for identifying diabetic patients at risk of dementia for early prevention strategies.
|
30308512 |
2018 |
Presenile dementia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Availability of social support appears to be associated with increased BDNF levels and, in certain subsets, reduce risk of subsequent dementia and stroke, thus warranting study of these pathways to understand their role in neuroprotection.
|
29067329 |
2017 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
While the exercise-dependent regulation of BDNF is currently undeniable, the role of exercise dependent BDNF as a tool for the improvement of EFs in individuals with dementia is still less clear and seldom discussed.
|
28469588 |
2017 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increasing levels of S100B, platelet-derived growth factor-AA (PDGF-AA), brain-derived neurotrophic factor (BDNF), and sRAGE were associated with decreased odds of mild neurocognitive disorder (n = 22) or HIV-associated dementia (n = 15) compared with normal function (n = 30) or asymptomatic neurocognitive impairment (n = 11).
|
27995575 |
2017 |
Presenile dementia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the present study, the mRNA and protein expression level of BDNF was detected in serum, and cerebrospinal fluid (CSF) of patients with mild cognitive impairment (MCI), dementia of Alzheimer's type (DAT), and hippocampus in APP/PS1 mice.
|
27545218 |
2016 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and post-stroke dementia: a hospital-based study from northern Iran.
|
27071687 |
2016 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The current study examined the association of BDNF genotype and plasma BDNF with hippocampal volume and memory in two large independent cohorts of middle-aged and older adults (both cognitively normal and early-stage dementia).Sample sizes ranged from 123 to 649.
|
25784293 |
2015 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, soluble Aβ42 and BDNF, but not TrkB or soluble tau, correlate with dementia in the oldest-old.
|
26410307 |
2015 |
Presenile dementia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lower BDNF and NGF levels were also observed in the sub-sample of MCI patients who progressed to dementia upon follow-up (p = 0.02 and p = 0.002, respectively).
|
25737042 |
2015 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We used Cox models to relate BDNF levels to the risk for dementia and AD and adjusted for potential confounders.
|
24276217 |
2014 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
To investigate the genetic effect of BDNF on cognitive function and regional WMH in the healthy elderly population, 90 elderly men, without dementia, with a mean age of 80.6 ± 5.6 y/o were recruited to undergo cognitive tests, structural magnetic resonance imaging (MRI) scans, and genotyping of BDNF alleles.
|
24275008 |
2014 |
Presenile dementia
|
0.400 |
Biomarker
|
disease |
BEFREE |
As a result, there has been a growing interest in the role of BDNF in neuropsychiatric disorders associated with neurodegeneration, including depression and dementia.
|
24070857 |
2013 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among 215 outpatients with dementia and MCI, 155 with mild AD (n = 108) or A-MCI (n = 47) were recruited and divided into three genotypic groups based on the representative NT-3 functional polymorphisms rs6332 and rs6489630.
|
23075484 |
2012 |
Presenile dementia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study investigated modification by BDNF val66met polymorphism of the association between physical activity, incident dementia and other cognitive outcomes.
|
20172629 |
2011 |