BDNF, brain derived neurotrophic factor, 627

N. diseases: 992; N. variants: 56
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE However, little is known about the relationship between memory performance and depression severity, about the course of memory performance during antidepressant treatment as well as about the relationship between memory performance and brain-derived neurotrophic factor (BDNF). 30929060 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE Major depressive disorder (MDD) is associated with stress-induced immune dysregulation and reduced brain-derived neurotrophic factor (BDNF) levels in sensitive brain regions associated with depression. 31532659 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 GeneticVariation disease BEFREE The association between BDNF Val66Met and SI was modeled using logistic regression adjusted for age and sex, and in secondary analyses also for depression. 30329132 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE In PSD patients, the presence of stroke may contribute to the development of depression, including affecting the expression of BDNF. 31385340 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE Additionally, elevated miR-133b and inhibited CTGF could restrain apoptosis of hippocampal neurons, repress inflammatory reaction, and increase the expression of GFAP, BDNF and neurotransmitters in hippocampal tissues of depression rats, resulting in a protective impact on neural injury in depression rats. 31830619 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Importantly, early life stressors that affect BDNF production are known to predispose individuals towards the later development of depression or anxiety disorders. 31568835 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE Reduced levels of brain derived neurotrophic factor (BDNF), through its role in neurogenesis and neuroplasticity, may be involved in the evolution and maintenance of depression. 31364951 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 GeneticVariation disease BEFREE Clinical and preclinical studies have demonstrated that depression, one of the most common psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF), contributing to neuronal atrophy in the prefrontal cortex (PFC) and hippocampus, and reduced hippocampal adult neurogenesis. 31830487 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE The proposed model is testable and implies that low levels and low variability in serum BDNF are associated with poor response to anti-depressive medications, electroconvulsive therapy, and REM sleep deprivation, in patients with depression. 31782101 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE The specific aim of this study was to explore the relationships between biomarkers of neural health: nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), immune health: interleukin 6 (IL-6), c-reactive protein (CRP), and cortisol, as well as the presence of depression, in physically active cannabis users (CU) and non-users (NU). 31319037 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE So far, the evidences suggested the presence of decreased BDNF concentrations in perinatal depressive disorders. 31416610 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE The aim of this study was to investigate the effects of probiotic and synbiotic supplementation on the depression and anxiety symptoms and serum brain-derived neurotrophic factor (BDNF) level. 31379269 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE PD is at least equally effective in reducing serum BDNF levels as depression. 30296429 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE It was proposed that seizure quality reflected by the SQI will be positively correlated with the levels of serum BDNF after ECT in patients with depression. 30978454 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE Effect of aerobic exercise on BDNF/proBDNF expression in the ischemic hippocampus and depression recovery of rats after stroke. 30500428 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE These results strongly implicate changes in BDNF levels in serum and the nucleus accumbens in the pathophysiology and treatment of early life combined stress-induced depression and highlight the therapeutic potential of escitalopram and new generation antipsychotic blonanserin for treatment-resistant refractory depression. 30658246 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE This is the first double-blind randomized placebo-controlled clinical trial that explored the modulation of BDNF in response to a psychedelic in patients with depression. 31231276 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE In our previous in vivo studies using ischemic and depression mouse models, we revealed that citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) exerts neuroprotective effects by enhancing the expression of BDNF in astrocytes within the hippocampus. 31195342 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1. 30529315 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE BDNF levels were negatively correlated and IL-1β and TNF-α levels were positively correlated with Hamilton Depression Rating Scale-24 scores. 30616482 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE This review describes (1) different 5-HT functioning in the embryonic (as neurotrophin) and adult brain (as a neurotransmitter); (2) BDNF as a modulator of 5-HT system and vice versa; (3) the prolonged positive effect of BDNF on genetically and epigenetically defined central nervous system disorders; (4) The 5-HT-BDNF interplay contribution to aggressive behavior, depression, drug addiction, suicide, and stress response; and (5) the role of common second messengers for 5-HT and BDNF signaling in the 5-HT-BDNF interaction. 30661441 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Significant correlations were noted between the BDNF concentrations and suicide ideation or attempted suicide (<i>p</i><0.01), but not with HAMD24 or depression. 31308724 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE CONCLUSIONS In conclusion, T. officinale exerts significant antidepressant effects in a mouse model of depression by inhibition of corticosterone levels and modulation of Mkp-1 and Bdnf expression. 30636257 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 Biomarker disease BEFREE Further research should focus on exploration of a link between BDNF and leptin underlying neuronal plasticity in depression. 31465895 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.600 AlteredExpression disease BEFREE To evaluate the effect of vortioxetine combined with cognitive behaviour intervention on the level of brain-derived neurotrophic factor (BDNF) in the serum of patients with depression and its therapeutic effect. 30780196 2019