BDNF, brain derived neurotrophic factor, 627

N. diseases: 992; N. variants: 56
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE Preliminary evidence suggests that BDNF (brain derived neurotrophic factor) rs6265 genetic polymorphism, BDNF gene promotor methylation and BDNF serum levels might play an important role in the pathogenesis of affective disorders. 30929061 2020
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 AlteredExpression group BEFREE Association between serum BDNF levels and maternal perinatal depression: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. 31416610 2020
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Therefore, in this review, we focus on the recent progress of BDNF in influencing mood disorders, by participating in alterations of the neuroimmune axis. 31231295 2019
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 AlteredExpression group BEFREE We used two different enzyme-linked immunosorbent assays kits to discriminate circulating levels of pro-BDNF and BDNF.Eight weeks of oral <i>H. erinaceus</i> supplementation decreased depression, anxiety, and sleep disorders.<i>H. erinaceus</i> supplementation improved mood disorders of a depressive-anxious nature and the quality of the nocturnal rest.<i>H. erinaceus</i> increased circulating pro-BDNF levels without any significant change in BDNF circulating levels. 31118969 2019
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE The role of brain-derived neurotrophic factor (BDNF) and its receptor TrkB has been studied in the context of mood disorders and their treatments for a couple of decades. 30637517 2019
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE The impact of BDNF Val66Met polymorphism on cognition in Bipolar Disorder: A review: Special Section on "Translational and Neuroscience Studies in Affective Disorders" Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders. 30078664 2019
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE The serotonin transporter (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) gene polymorphisms have been associated with risk for affective disorders and functional variability of the amygdala. 30711709 2019
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE This provides a novel molecular framework for understanding how brain networks use BDNF and glucocorticoid signaling contingencies to forge receptive neuronal fields in temporal domains defined by behavioral experience, and in mood disorders. 30572337 2019
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Evidence supports brain-derived neurotrophic factor (BDNF) and its primary receptor tyrosine-related kinase B (TrkB) as targets in the treatment of mood disorders. 30995444 2019
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism has been associated with increased susceptibility to develop mood disorders and recently it has been also linked with cardiovascular disease (CVD). 30347685 2018
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE In conclusion, this study suggests the presence of a disturbance in the endogenous synthesis of DHEA and DHEAS in mood disorders, which has a close relationship with BDNF-TrkB signaling. 28752602 2018
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Apart of the secretion of the pro-inflammatory cytokines, SD affects production of brain-derived neurotrophic factor (BDNF) while release of BDNF from astrocytes appears a key contributor to mood disorders. 30666218 2018
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE The BDNF Val66Met polymorphism may confer risk for mood disorders in females through effects on amygdala-cortical connectivity during adolescence, coinciding with a period in the lifespan when onset of depression often occurs, more commonly in females. 28387866 2018
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Neuroepigenetics of Neurotrophin Signaling: Neurobiology of Anxiety and Affective Disorders. 30072053 2018
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE Stress-induced changes in the hippocampus have been implicated in mood disorders, and mutations in several genes have now been associated with increased risk, such as brain-derived neurotrophic factor (BDNF). 27956743 2018
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE The potential role of altered HPA axis, epigenetics, NPY, BDNF, neurosteroid biosynthesis, the endocannabinoid system, and their function as biomarkers for mood disorders is discussed. 30394136 2018
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 AlteredExpression group BEFREE Low serum BDNF levels are associated with characteristics related to alcohol consumption and mood disorders, and variants of the BDNF gene in alcohol use disorder patients. 28485899 2017
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE A number of preclinical studies emphasize the essential role of brain-derived neurotrophic factor (BDNF) in the pathophysiology of mood disorders. 28427565 2017
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Many evidences show that BDNF is critically decreased in mood disorders and plays an essential role in most anti-depressant treatments. 28078988 2017
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE We will here review these data and discuss new insights into the possible pathophysiological roles of those new BDNF subtypes as well as recent findings on the role of BDNF mediated neuronal plasticity in mood disorders and their treatments. 27425886 2017
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE The molecular mechanisms underlying such regulations may rely upon long-term changes in stress-responsive effectors such as Brain-Derived Neurotrophic Factor (BDNF) that can affect neuronal plasticity underlying mood disorders and may also play a role in metabolic regulation. 28706476 2017
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 Biomarker group BEFREE Sigma-1 receptor can modulate a number of central neurotransmitter systems as well as some other signaling pathways (e.g., neurotrophin and growth factor signaling) which are seemingly involved in BD and other mood disorders. 28144920 2017
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE The BDNF Val66Met polymorphism has been associated with sensitivity to stress and affective disorders. 28926000 2017
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE Inhibition of stress-induced elevations in brain-derived neurotrophic factor (BDNF) or its primary receptor tyrosine-related kinase B (TrkB) within the reward pathway may modulate vulnerability to anxiety and mood disorders. 28257759 2017
CUI: C0525045
Disease: Mood Disorders
Mood Disorders
0.400 GeneticVariation group BEFREE Further, 2 genetic polymorphisms: the 5-HTTLPR and the brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms were not directly associated with familial risk for affective disorder and did not predict illness onset. 27697135 2016