Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 AlteredExpression disease BEFREE The findings showed lower levels of endocannabinoids and BDNF in the ventral striata of MDD patients and WKY rats. 31654971 2020
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 AlteredExpression disease BEFREE Elevated levels of proinflammatory cytokines and reduced BDNF levels lead to impaired synaptic plasticity mechanisms that contribute to the pathophysiology of MDD. 31532659 2020
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Taken together, our results revealed differential changes of BDNF-TrkB signaling in MDD and SCZ patients, therefore contributed to a better understanding of MDD and SCZ pathophysiology. 31711978 2020
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE This study suggests that in patients who have experienced AIS, there is no significant relationship between major depression and basal proinflammatory cytokines (TNF-α, IL-1 β, IL-18), BDNF, and NSE. 31142907 2020
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE As studies testing the BDNF system across molecular levels are sparse, this study aimed at investigating the BDNF val66met genotype, BDNF DNA methylation changes and peripheral BDNF serum levels in acute and remitted phases of MDD (major depressive disorder) and BD (bipolar disorder) and healthy controls. 30929061 2020
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Our results corroborate a concomitant amelioration of learning and delayed recall dysfunctions with successful antidepressant therapy in a subgroup of patients and support a role of BDNF in the neural mechanisms underlying the normalization of memory dysfunctions in MDD. 30929060 2020
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 AlteredExpression disease BEFREE In our sample, baseline serum BDNF levels did not predict major depression and the clinical characteristics of the patients did not predict their BDNF levels. 31231276 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression. 31721892 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE These findings demonstrate that the BDNF pro-peptide is a biologically important synaptic modulator and is associated with MDD, particularly in males. 31076872 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Brain derived neurotrophic factor (BDNF) has been linked to the etiology and pathology of Major Depressive Disorder (MDD). 31449911 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE The BDNF concentrations were significantly lower in MDD (947±297 vs 1187±236 pg/mL, <i>p</i>=0.019), in MDD with attempted suicide than those without (779±231 vs 993±298, <i>p</i>=0.024) at the baseline. 31308724 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 AlteredExpression disease BEFREE In conclusion, these results showed that BDNF exon IX promoter methylation levels, serum BDNF protein level, and serum BDNF mRNA level could contribute to the pathophysiology of a major depressive disorder. 31027379 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE Association between serotonin 2A receptor (HTR2A), serotonin transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene polymorphisms and citalopram/sertraline induced sexual dysfunction in MDD patients. 31792367 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Our findings show an association between low serum BDNF and SI in individuals with less than severe and non-active suicidal intent, suggesting that the individual symptom of suicidality may extend the neurotrophic hypothesis of depression to include suicidal ideation within MDD. 30640051 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE The role of interactions between BDNF genetic and epigenetic variations with MDD diagnosis, sex, and Childhood Trauma Questionnaire (CTQ) scores was also explored. 31636250 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Brain-derived neurotrophic factor (BDNF), an essential factor for maintaining brain functions, has been reported to be reduced in various neurological diseases, including Alzheimer's disease and major depression. 30753865 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Together, results from these preclinical studies conclude that decreased AR may accelerate the stress-induced MDD via altering miR-204-5p/BDNF/AKT/MAPK signaling, and targeting this newly identified signaling may help in the development of better therapeutic approaches to reduce the development of MDD. 31480771 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Our results support that BDNF demonstrated moderate accuracy in distinguishing male patients with MDD and female patients with SZ from HCs. 30794585 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 AlteredExpression disease BEFREE : The results suggest that the existence of major depression in pregnant women may negatively affect fetal circulating BDNF levels. 30905131 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Our findings provide further evidence for an interaction of the HPA axis and the neurotrophin system in major depression. 31295515 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 AlteredExpression disease BEFREE Taken together, the results suggest that reduced CSF BDNF pro-peptide levels are associated with MDD, particularly in males. 30986693 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE We investigated treatment response and pre-treatment leptin and BDNF in patients with MDD and with panic disorder (PD). 31465895 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 GeneticVariation disease BEFREE Findings from this study indicated that having BDNF rs6265 in the Malaysian population increase the odds of developing MDD by 2.05 folds (95% CI = 1.48-3.65). 30677092 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Decrease of brain-derived neurotrophic factor (BDNF) in the brain is one of the proposed mechanisms for the major depressive disorders, and Neurotropin has been reported to restore the decreased BDNF in the hippocampus. 31188139 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker disease BEFREE Brain-derived neurotrophic factor (BDNF) is a neurotrophin with a well-established role in MDD etiopathology: it is altered in depressed patients as well as in animal models of the disease and its changes are restored by antidepressant drugs. 31379496 2019