Autism Spectrum Disorders
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The current project aimed at comparison of transcript levels of brain derived neurotrophic factor (BDNF), beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), and their natural occurring antisenses in the peripheral blood of ASD individuals (n = 50, male/female = 38/12, age (mean ± standard deviation (SD)): 6 ± 1.4, age range: 3-8) and matched healthy persons (n = 50, male/female = 37/13, age (mean ± SD): 6 ± 1.74, age range: 3-8).
|
31760580 |
2020 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
We performed a nested case-control study of the relation between blood levels of neuro-developmental (S100B, BDNF, and VEGF-A) and inflammatory (MCP-1, TARC, IL-8, IL-18, CRP, and IgA) biomarkers in newborns, and later development of autism spectrum disorders (ASD, N = 751), attention deficit hyperactivity disorders (ADHD, N = 801), schizophrenia (N = 1969), affective (N = 641) or bipolar disorders (N = 641).
|
31591381 |
2019 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
Dysregulation of neurotrophins such as BDNF and their signaling pathways have been implicated in ASD.
|
29691724 |
2018 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increased BDNF production and changes in the metabolism of tryptophan are associated with many ASD characteristics, showing particularly strong associations with childhood autism and Intellectual and Developmental Disabilities.
|
30033880 |
2018 |
Autism Spectrum Disorders
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Having a child with ASD raises the BDNF levels in parents comparing to controls.
|
29532458 |
2018 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
As most of this work has investigated the role of brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) in ASD formation, we focus on these two molecules in this review.
|
28551754 |
2017 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
And, the BDNF genotyping results showed that there was no difference between the ASD cases and the control.
|
26820673 |
2017 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
Sexually Dimorphic Epigenetic Regulation of Brain-Derived Neurotrophic Factor in Fetal Brain in the Valproic Acid Model of Autism Spectrum Disorder.
|
29073621 |
2017 |
Autism Spectrum Disorders
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Meanwhile, in ASD group, the average escape latency and the frequency of crossing plates were decreased, the apoptotic index (AI) detected by TUNEL assay was increased, and the expression of brain-derived neurotrophic factor (BDNF) and B-cell lymphoma 2 (Bcl-2) analyzed was decreased with great difference compared with normal group (<i>P</i><0.01).
|
28360521 |
2017 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
We find that translation of dyrk1a, a Down syndrome- and autism spectrum disorders-related gene, is dependent on Mena, both in steady-state conditions and upon BDNF stimulation.
|
28735747 |
2017 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present meta-analysis study led to conclusion that BDNF might play role in autism initiation/ propagation and therefore it can be considered as a possible biomarker of ASD.
|
28138831 |
2017 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this concise review, we summarize the current evidence that supports the role of brain-derived neurotrophic factor, insulin-like growth factor 2, hepatocyte growth factor (HGF), glial-derived neurotrophic factor, nerve growth factor, neurotrophins 3 and 4, and epidermal growth factor in the pathogenesis of ADHD and ASD.
|
28751869 |
2017 |
Autism Spectrum Disorders
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Aberrant cognitive phenotypes and altered hippocampal BDNF expression related to epigenetic modifications in mice lacking the post-synaptic scaffolding protein SHANK1: Implications for autism spectrum disorder.
|
28500650 |
2017 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
Emerging promise of amitriptyline in ASD is discussed, together with promising BDNF effects of loxapine and amitriptyline.
|
28335658 |
2017 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
This meta-analysis suggests that peripheral BDNF levels are a potential biomarker of ASD.
|
27506602 |
2016 |
Autism Spectrum Disorders
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Neither BDNF Val66Met genotype nor plasma BDNF was significantly associated with the presence or severity of ASD or PTSD.
|
26999419 |
2016 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
An increase in the size of the patient cohort seems necessary to ascertain whether decreased IL-18 content in the sera can become a predictive biomarker of ASD and whether its measure, in combination with other markers (e.g., increased levels of brain-derived neurotrophic factor (BDNF)), may be included in a diagnostic panel.
|
26728085 |
2016 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
Discovery of the lncRNAs of SHANK2-AS and BDNF-AS, the natural antisense of genes SHANK2 and BDNF, respectively, indicates that in addition to gene mutations, deregulation of lncRNAs on ASD-causing gene loci presents a new approach for exploring possible epigenetic mechanisms underlying ASD.
|
26485544 |
2015 |
Autism Spectrum Disorders
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Neurotrophin blood-based gene expression and social cognition analysis in patients with autism spectrum disorder.
|
25535174 |
2015 |
Autism Spectrum Disorders
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lack of microglial phagocytosis and decreased levels of BDNF appear to distinguish Rett syndrome from ASDs, in which there is instead microglia activation and/or proliferation and possibly defective BDNF signaling.
|
25669997 |
2015 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
CTD_human |
Disrupted brain thyroid hormone homeostasis and altered thyroid hormone-dependent brain gene expression in autism spectrum disorders.
|
24781735 |
2014 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using diagnostic measures and clinical judgement, 3 subjects (2 BDNF+/- and 1 BDNF+/+) in the WAGR group (10.7%) were classified with autism spectrum disorder.
|
23517654 |
2014 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples.
|
19582565 |
2009 |