Intellectual Disability
|
0.500 |
AlteredExpression
|
group |
BEFREE |
We further found that significant decreases in the BDNF-protein level in the medial prefrontal cortex of ATR-X model mice were recovered with treatment of SA4503.
|
30231518 |
2018 |
Intellectual Disability
|
0.500 |
AlteredExpression
|
group |
BEFREE |
Elevated BDNF levels and lower tryptophan and KA levels were characteristics of both childhood autism and intellectual disability disorder, whilst elevated tryptophan and lower 5-HT synthesis were hallmarks of Asperger syndrome.
|
30033880 |
2018 |
Intellectual Disability
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The new ARID genes include nine with loss-of-function mutations (ABI2, MAPK8, MPDZ, PIDD1, SLAIN1, TBC1D23, TRAPPC6B, UBA7 and USP44), and missense mutations include the first reports of variants in BDNF or TET1 associated with ID.
|
28397838 |
2018 |
Intellectual Disability
|
0.500 |
AlteredExpression
|
group |
BEFREE |
BDNF serum levels were measured in 45 ASD children without intellectual disability (ID) and allergies, age 30-42 months and age-matched normal controls.
|
29532458 |
2018 |
Intellectual Disability
|
0.500 |
Biomarker
|
group |
BEFREE |
Since the positive effect of exercise was paralleled by increased BDNF expression in trisomic mice, we investigated the effectiveness of a BDNF-mimetic treatment with 7,8-dihydroxyflavone at alleviating intellectual disabilities in the DS model.
|
29203796 |
2017 |
Intellectual Disability
|
0.500 |
Biomarker
|
group |
BEFREE |
In addition, we present the first results suggesting that these BDNF SNPs are significantly associated with ID.
|
20943059 |
2010 |
Intellectual Disability
|
0.500 |
Biomarker
|
group |
BEFREE |
Heterozygous, variably sized, contiguous gene deletions causing haploinsufficiency of the WT1 and PAX6 genes on chromosome 11p13, approximately 4 Mb centromeric to BDNF (11p14.1), result in the Wilms' tumor, aniridia, genitourinary anomalies, and mental retardation (WAGR) syndrome.
|
18753648 |
2008 |
Intellectual Disability
|
0.500 |
Biomarker
|
group |
BEFREE |
Literature review on the functions of the genes suggests that haploinsufficiency of SLC1A2, PRRG4, and BDNF may contribute to mental retardation and behavioral problems.
|
19096215 |
2008 |
Intellectual Disability
|
0.500 |
Biomarker
|
group |
CTD_human |
Neonatal concentrations of VIP, CGRP, BDNF, and NT4/5 were higher (ANOVA, all p values < 0.0001 by Scheffe test for pairwise differences) in children in the autistic spectrum and in those with mental retardation without autism than in control children.
|
11357950 |
2001 |
Intellectual Disability
|
0.500 |
Biomarker
|
group |
BEFREE |
Two eSTS markers have been further mapped with respect to a yeast artificial chromosome (YAC) contig close to the brain-derived neurotrophic factor (BDNF) gene and thus provide potential candidate genes for the mental retardation phenotype of WAGR (Wilms' tumor, aniridia, genitourinary abnormalities and mental retardation) syndrome.
|
8717056 |
1995 |
Intellectual Disability
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The brain-derived neurotrophic factor (BDNF) gene maps to this region, and its deletion seems to contribute to the severity of the patients' mental retardation.
|
7896291 |
1994 |
Intellectual Disability
|
0.500 |
Biomarker
|
group |
HPO |
|
|
|