Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.500 AlteredExpression group BEFREE We further found that significant decreases in the BDNF-protein level in the medial prefrontal cortex of ATR-X model mice were recovered with treatment of SA4503. 30231518 2018
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.500 AlteredExpression group BEFREE Elevated BDNF levels and lower tryptophan and KA levels were characteristics of both childhood autism and intellectual disability disorder, whilst elevated tryptophan and lower 5-HT synthesis were hallmarks of Asperger syndrome. 30033880 2018
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.500 GeneticVariation group BEFREE The new ARID genes include nine with loss-of-function mutations (ABI2, MAPK8, MPDZ, PIDD1, SLAIN1, TBC1D23, TRAPPC6B, UBA7 and USP44), and missense mutations include the first reports of variants in BDNF or TET1 associated with ID. 28397838 2018
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.500 AlteredExpression group BEFREE BDNF serum levels were measured in 45 ASD children without intellectual disability (ID) and allergies, age 30-42 months and age-matched normal controls. 29532458 2018
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.500 Biomarker group BEFREE Since the positive effect of exercise was paralleled by increased BDNF expression in trisomic mice, we investigated the effectiveness of a BDNF-mimetic treatment with 7,8-dihydroxyflavone at alleviating intellectual disabilities in the DS model. 29203796 2017
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.500 Biomarker group BEFREE In addition, we present the first results suggesting that these BDNF SNPs are significantly associated with ID. 20943059 2010
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.500 Biomarker group BEFREE Heterozygous, variably sized, contiguous gene deletions causing haploinsufficiency of the WT1 and PAX6 genes on chromosome 11p13, approximately 4 Mb centromeric to BDNF (11p14.1), result in the Wilms' tumor, aniridia, genitourinary anomalies, and mental retardation (WAGR) syndrome. 18753648 2008
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.500 Biomarker group BEFREE Literature review on the functions of the genes suggests that haploinsufficiency of SLC1A2, PRRG4, and BDNF may contribute to mental retardation and behavioral problems. 19096215 2008
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.500 Biomarker group CTD_human Neonatal concentrations of VIP, CGRP, BDNF, and NT4/5 were higher (ANOVA, all p values < 0.0001 by Scheffe test for pairwise differences) in children in the autistic spectrum and in those with mental retardation without autism than in control children. 11357950 2001
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.500 Biomarker group BEFREE Two eSTS markers have been further mapped with respect to a yeast artificial chromosome (YAC) contig close to the brain-derived neurotrophic factor (BDNF) gene and thus provide potential candidate genes for the mental retardation phenotype of WAGR (Wilms' tumor, aniridia, genitourinary abnormalities and mental retardation) syndrome. 8717056 1995
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.500 GeneticVariation group BEFREE The brain-derived neurotrophic factor (BDNF) gene maps to this region, and its deletion seems to contribute to the severity of the patients' mental retardation. 7896291 1994
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability
0.500 Biomarker group HPO