S100B, S100 calcium binding protein B, 6285

N. diseases: 599; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 Biomarker disease BEFREE Alteration of specific neurotrophic factors such as glial cell line-derived neurotrophic factor and S100B may be an important feature of BD. 27772534 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 GeneticVariation disease BEFREE Higher mean serum S100B levels were associated with the risk G allele of rs3788266 in BPAD cases (P = 0.0001), unaffected relatives of BPAD cases (P < 0.0001) and unrelated controls (P < 0.0001). 21714070 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 GeneticVariation disease BEFREE Recently, associations were found between variations in the S100B gene and schizophrenia as well as bipolar affective disorder. 21112154 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 Biomarker disease PSYGENET Recently, associations were found between variations in the S100B gene and schizophrenia as well as bipolar affective disorder. 21112154 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 Biomarker disease PSYGENET Higher mean serum S100B levels were associated with the risk G allele of rs3788266 in BPAD cases (P = 0.0001), unaffected relatives of BPAD cases (P < 0.0001) and unrelated controls (P < 0.0001). 21714070 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 Biomarker disease PSYGENET These genes include GRM7, previously associated to major depression disorder and bipolar disorder, SLC6A13, in anxiety disorders, and S100B, SSTR5 and COMT in schizophrenia. 20398908 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 Biomarker disease PSYGENET Fine-mapping analyses of 21q22 have previously identified transient receptor potential gene melastatin 2 (TRPM2), which is 2 Mb upstream of S100B, as a possible BPAD susceptibility gene at 21q22. 17525977 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 Biomarker disease BEFREE Fine-mapping analyses of 21q22 have previously identified transient receptor potential gene melastatin 2 (TRPM2), which is 2 Mb upstream of S100B, as a possible BPAD susceptibility gene at 21q22. 17525977 2007
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 Biomarker disease CTD_human Regionally specific changes in levels of cortical S100beta in bipolar 1 disorder but not schizophrenia. 16476148 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 Biomarker disease RGD Our findings reinforce the role of astroglial cells in the pathogenesis of bipolar disorder and S100B protein as a marker of bipolar mania. 15581912 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.740 Biomarker disease CTD_human Our findings reinforce the role of astroglial cells in the pathogenesis of bipolar disorder and S100B protein as a marker of bipolar mania. 15581912 2004
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease BEFREE Serum S100B can be used as a biomarker of depression. 30745657 2020
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease BEFREE Notably, ketamine increased the proliferation of NPCs independent of the NMDA receptor, while transcriptome analysis revealed significant upregulation of insulin-like growth factor 2 (IGF2) and p11, a member of the S100 EF-hand protein family, which are both implicated in the pathophysiology of depression, 24 h after ketamine treatment. 31554266 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease BEFREE Using a cohort of 86 pregnant women, we found that SSRIs significantly increase BDNF levels in late pregnancy and that S100B, but not BDNF, is associated with maternal depression in SSRI-treated women only. 30506371 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 AlteredExpression disease BEFREE Patients with S100B levels in the intermediate tertile, that is, between 33 ng/L and 53 ng/L, had higher odds on remission, odds ratio: 5.5 (95%Confidence Interval (CI): 1.55-19.20, p = <0.01), and were more likely to remit from depression over time, hazard ratio: 1.96 (95%CI: 1.04-3.72, p = 0.04), compared with patients in the lowest tertile. 31493698 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 AlteredExpression disease BEFREE ANCOVA analysis followed by heteroscedasticity-consistent covariance matrix was performed to evaluate BDNF and S100B levels, adjusted for depression severity, pain levels and use of analgesics according different pathologies. 31100426 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease BEFREE EGb, as an adjunctive treatment, can effectively improve depressive symptoms and reduce expression of serum S100B, which is a marker of brain injury, suggesting that EGb restores neurologic function during the treatment of depression in elderly patients and S100B participates in the therapeutic mechanism. 30278520 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease BEFREE Alpha1-antitrypsin (A1AT), FAS, Heparin-binding EGF-like Growth Factor (HB-EGF), Insulin-like Growth Factor-1 (IGF-1), Luteinizing Hormone (LH), Macrophage Inflammatory Protein type 1 alpha (MIP-1α), Resitin, S100b, Tissue Inhibitor of Metalloproteinase type 1 (TIMP-1), and Vascular Cell Adhesion Molecule type 1 (VCAM-1) each were partial mediators of depression's association with δ. 28594820 2017
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease RGD Brain-derived neurotrophic factor (BDNF) infusion restored astrocytic plasticity in the hippocampus of a rat model of depression. 21843601 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. 20962330 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET Significant differences in the subgroup depression (first-episode and recurrent depression) were also shown in 3 genotypes of S100B rs9722 and rs11911834 in patients and control subjects (P < 0.05). 19497163 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 GeneticVariation disease BEFREE Significant differences in the subgroup depression (first-episode and recurrent depression) were also shown in 3 genotypes of S100B rs9722 and rs11911834 in patients and control subjects (P < 0.05). 19497163 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET Although it may be open for discussion whether the neuroprotective effects of ONO-2506 are exclusively due to its inhibition of S100B synthesis, the latter action of ONO-2506 warrants studies of the effects of this drug in the pathobiology of depression. 16797859 2006
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease BEFREE Although it may be open for discussion whether the neuroprotective effects of ONO-2506 are exclusively due to its inhibition of S100B synthesis, the latter action of ONO-2506 warrants studies of the effects of this drug in the pathobiology of depression. 16797859 2006
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker disease PSYGENET S100 beta, a calcium binding brain protein expressed by astrocytes, has been shown to be involved in higher neural processes, including hippocampal-dependent behavioral traits and hippocampal neuronal long-term potentiation (LTP) and depression (LTD), neurophysiological phenomena that may be involved in exploring, learning and remembering novel stimuli. 8804639 1996