CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 Biomarker disease RGD Neutralization of MCAF/MCP-1 is beneficial by preventing reperfusion injury in a rat model of myocardial ischemia and reperfusion. 10068207 1999
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 GeneticVariation disease BEFREE Our data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is not strongly associated with IHD. 15245376 2004
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 GeneticVariation disease BEFREE Odds ratios (OR) with 95% confidence interval (CI) were used to evaluate the strength of associations between the MCP-1 A-2518G polymorphism (rs1024611) and IHD and IS susceptibilities. 25413568 2015
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 Biomarker disease RGD Prolonged cold ischemia in rat cardiac allografts promotes ischemia-reperfusion injury and the development of graft coronary artery disease in a linear fashion. 16297799 2005
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 Biomarker disease BEFREE However, the gene expression changes caused by signal transduction, triggered by MCP-1 binding to its receptor CCR2, and their possible role in the development of IHD are not understood. 16574901 2006
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 Biomarker disease BEFREE Recent studies have indicated that monocyte chemoattractant protein-1 (MCP-1) plays an important role in the initiation and progression of ischaemic heart disease. 31077149 2019
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia
0.550 GeneticVariation disease BEFREE The aim of our work was to find if MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) influences somehow the serum concentrations of high-sensitive CRP (hsCRP) both in patients suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP), and hypertension (HT) and in control group of healthy subjects. 19639050 2009