Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We observed that supplementation with 500 μg/Kg body weight (b.w.) eNPs significantly restored the levels of thiobarbituric acid reactive substances, COX-2 activity, different antioxidant enzyme activities, and inflammatory cytokines (TNF-α, IL-1β, IL-6, and MCP-1) in RA rats.
|
30718447 |
2019 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Peficitinib suppressed the secretion of MCP-1/CCL2 in the RA FLS supernatant (<i>p</i> < 0.05).
|
31181818 |
2019 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, increased levels of IL-1β, IL-6, and MCP-1 were detected in the patients with RA compared to healthy controls.
|
30809737 |
2019 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whereas, CM3D was characterised by a prevailing expression of anti-inflammatory cytokines such as IL-10 and LIF, along with trophic factors involved in different mechanisms leading to tissue regeneration, such as PDGF-BB, FGF-2, I-309, SCF, and GM-CSF; CM2D presented relatively higher levels of IL-6, MCP-1, and IL-21, with recognised pro-inflammatory roles in joint disease and pleiotropic effects in the progression of rheumatoid arthritis (RA).
|
30804924 |
2019 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
When stimulated with FFA, osteoblasts from RA and OA patients secreted higher amounts of the proinflammatory cytokine interleukin (IL)-6 and the chemokines IL-8, growth-related oncogene α, and monocyte chemotactic protein 1.
|
31849953 |
2019 |
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
No relation of miR-124 expression to measures of RA activity (DAS28 score; TSS), auto-antibodies (anti-CCP, RF, RF IgG, RF IgA, RF IgM), acute inflammatory markers (CRP, IL-6), and other cytokine and chemokines (IL-13, IL-15, IL-8, TNF-α, MCP-1, RANTES) was observed.
|
30431436 |
2018 |
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the effect of a knockdown of caveolin-1 (CAV1), a known regulator of multiple cell signaling pathways, on chemokine (C-C motif) ligand 2/monocyte chemoattractant protein-1 (CCL2/MCP-1) expression in synovial fluid-derived fibroblast-like synoviocytes (sfd-FLSs) obtained from patients with RA.
|
30079994 |
2018 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results indicate that neutrophil autophagy may be a novel perspective to understand the pathology which may provide a new maker to diagnose RA and IL-8, IL-10, MCP-1 specific antagonists and neutrophil autophagy target inhibitors may improve the therapeutic effect of RA someday.
|
30312880 |
2018 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The chemokine receptors CCR2 and CX3CR1 expressed by monocytes interact with chemokine ligands CCL2 (MCP-1) and CX3CL1 (fractalkine) respectively produced by FLS and this interaction promotes their migration and recruitment into RA synovium.
|
30366278 |
2018 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recombinant CCL2 partially restored the decrease in migration and invasion of NFAT5-deficient RA-FLSs stimulated with IL-1β.
|
29794013 |
2018 |
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of several potential SOX5-targeted genes, including matrix metalloproteinases (MMP-1, 2, 3 and 9), chemokines (CCL4, CCL2, CCR5 and CCR2), and pro-inflammatory cytokines (TNF-α and IL-6), were examined in RA-FLS using SOX5 gain- and loss-of-function study.
|
29706965 |
2018 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to investigate the effects of leukotriene B4 (LTB4) on the expression of interleukin-32 (IL-32) interferon-γ (IFN-γ) and chemokine monocyte chemoattractant protein (MCP-1) and macrophage inhibitory protein (MIP-1α) in rheumatoid arthritis (RA).
|
28912850 |
2017 |
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pathway enrichment analysis revealed that DEGs mainly participated in the rheumatoid arthritis (CCL2, CSF1, IL11, LTB and MMP1), gematopoietic cell lineage (CD33, CD44, CSF1 and IL11) and TNF signaling pathway (CCL2, CSF1, MMP9 and VCAM1).
|
28336462 |
2017 |
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The stimulation with resistin increased the protein levels of CXCL8 and CCL2 produced by RA FLSs, and the upregulated expression of CXCL8 was inhibited by the abrogation of CAP1 by siRNA for CAP1.
|
29191223 |
2017 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specifically, CCL2 secretion in an NFAT5-dependent fashion bestowed apoptotic resistance to RA macrophages in vitro.
|
28192374 |
2017 |
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our study describes how CCN1 promotes monocyte migration by upregulating CCL2 expression in osteoblasts in RA disease.
|
28341837 |
2017 |
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Monocyte chemoattractant protein-1 (MCP-1, also called CCL2) is related to RA disease activity, and epigenetic modifications are hypothesized to regulate gene expression in RA pathogenesis.
|
28113136 |
2017 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF-induced mRNA stabilization in RA FLS occurs during the late phase of TNF response, is MAPK-dependent, and involves several genes with pathogenic potential such as IL6, CXCL1, CXCL3, CXCL8/IL8, CCL2, and PTGS2.
|
28708839 |
2017 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the RA group (n = 53), the joint space width measured in the MCP1, MCP3, MCP5 of the hand were reduced significantly (P < 0.01) by 16.4%, 15.6%, and 17.5%, respectively compared to the normal group (n = 17).
|
25865479 |
2017 |
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The -2518 A/G polymorphism in the monocyte chemoattractant protein 1 gene (MCP-1) is associated with an increased risk of rheumatoid arthritis in Argentine patients.
|
27530408 |
2016 |
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis showed that the MCP-1-2518-A allele confers susceptibility to Asian patients with RA and European patients with CD.
|
26318885 |
2016 |
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis revealed no association between the MCP-1 -2518 G allele and RA (OR = 0.986, 95% CI = 0.890-1.093, p = 0.793) or MS (OR = 1.281, 95% CI = 0.802-2.046, p = 0.301).
|
27064875 |
2016 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MCP-1 was associated with risk of RA, especially among HLA-SE positive, but did not differ by smoking status, BMI or alcohol intake.
|
26223686 |
2015 |
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Histological examination of rheumatoid joints revealed extensive CCL2 expression in RA ST.
|
26069140 |
2015 |
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
High CCR2 expression and responsiveness to CCL2 were observed in neutrophils from the blood of patients with early RA and in neutrophils from the blood and bone marrow of mice with AIA.
|
25779331 |
2015 |