|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Stress hyperglycemia and diabetes may contribute to high monocyte chemoattractant protein-1 levels and prolonged inflammation.
|
30988769 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
PubMed, Scopus, Embase, ProQuest and Google Scholar databases were searched to fined interventional studies from the effects of chromium on inflammatory biomarkers such as tumour necrosis factor a (TNF-a), C-reactive protein (CRP), interleukins, monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1) and adipocytokines in hyperglycaemia and diabetes.
|
31330062 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, the topical application of CCL2 can be an effective therapeutic option for the treatment of patients with diabetes with defective wound repair, promoting neovascularization and collagen accumulation at skin wound sites.
|
31247201 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combined treatment of PA and LPS in RAW264.7 cells mimics the situation of diabetes with obesity that has higher level of PA and LPS, MAPK/TLR4/ MCP-1 might be potential therapeutic targets for diabetes with obesity.
|
30909920 |
2019 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A logistic regression model adjusted for body mass index (BMI), age, race, aldosterone levels, and presence of diabetes and RH demonstrated that median levels of MCP-1 (2.55 pg/mL [1.22 - 5.2 pg/mL], p = 0.01) were independently associated with LVH in the entire hypertensive population.
|
28380135 |
2017 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Two-week infusion of RAGE-aptamer just after the induction of diabetes also inhibited the AGE-RAGE-oxidative stress system and MCP-1 levels in the kidneys of 8-week-old diabetic rats and simultaneously ameliorated podocyte injury and albuminuria.
|
28385802 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The highlights of this review include the roles of MCP-1 in development of diabetes, the evaluation of plant metabolites that specifically or non-specifically inhibit MCP-1 overproduction, and the molecular mechanisms of this activity.
|
28266270 |
2017 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multivariate Cox regression analysis, taking into the account the recipient's sex, age and BMI, as well as the number of G alleles of the CCL2 rs1024611 polymorphism, revealed that this polymorphism is an independent risk factor for post-transplant diabetes.
|
26802601 |
2016 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Obesity is associated with elevated monocyte chemoattractant protein-1 (MCP-1), a proinflammatory chemokine related to diabetes and cardiovascular disease.
|
25994074 |
2015 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggested that puerarin plays a critical role in transcriptional repression of high glucose-induced MCP-1 gene expression, at least in part due to alteration of H3K4me2/3 methylation, thus possesses a therapeutic potential in diabetes-induced vascular injuries.
|
25817234 |
2015 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There were no significant differences (P >0.05) in MCP1 distribution between the study groups and controls, independently of the occurrence of diabetes and responsiveness to hepatitis B vaccination.
|
24382482 |
2014 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Diabetes and CCL2 injection also induced activation of retinal microglia in these animals.
|
25329075 |
2014 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Effect of Danzhijiangtang capsule on monocyte chemoattractant protein-1 mRNA expression in newly diagnosed diabetes subclinical vascular lesions.
|
23704830 |
2013 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A nearly 1.5-fold higher expression of CaR(surf) on the peripheral blood monocytes of individuals with diabetes and PAD manifests during post-transcription stage and depends on fasting glucose concentration and MCP-1 concentration on one hand, and the severity of PAD on the other.
|
24101400 |
2013 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hyperglycemia induces MCP-1 production in vascular endothelial cells and retinal pigmented epithelial cells, and has been implicated as a causal factor in the facilitation of vascular complications in diabetes.
|
23549806 |
2013 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The -2518A/G polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene and diabetes risk: a meta-analysis.
|
21992868 |
2011 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Palmitate induced IL-6 and MCP-1 expression in human bladder smooth muscle cells provides a link between diabetes and urinary tract infections.
|
20526368 |
2010 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we investigated in vivo if glomerular CCR2 expression is altered in kidney biopsies from patients with diabetic nephropathy and whether lack of MCP-1 affects proteinuria and expression of nephrin in experimental diabetes.
|
19587356 |
2009 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
(3) Diabetes and high fat diet, which lead to a significant increase in inflammatory molecules and cytokines, including MCP-1, which induces changes in podocyte cytoskeleton and nephrin loss.
|
19077682 |
2009 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We performed in vitro and in vivo studies to examine whether MCP-1 may have prosclerotic actions in the setting of diabetes, presumably via its receptor, chemokine (C-C motif) receptor 2 (CCR2), which has been described in mesangial cells.
|
17968528 |
2008 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Researchers have found that diabetes induces kidney MCP-1 production and that urine MCP-1 levels can be used to assess renal inflammation in this disease.
|
18272603 |
2008 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Strong associations are observed between induction of RAGE mRNA and diabetes (P < 0.01) and between induction of RAGE and MCP-1 transcripts (P < 0.05).
|
15677796 |
2005 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Presence of the MCP-1 G-2518 allele was associated with decreased plasma MCP-1 ( p=0.017), a decreased prevalence of insulin resistance (odds ratio [OR]=0.82, 95% CI: 0.70-0.97, p=0.021) and a decreased prevalence of diabetes (OR=0.80, 95% CI: 0.67-0.96, p=0.014).
|
15349727 |
2004 |