Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 Biomarker group BEFREE Sequential and timely transfection of hepatocyte growth factor and monocyte chemotactic protein-1 ameliorates hyperkinetic pulmonary artery hypertension in rabbits. 25940417 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 Biomarker group CTD_human TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension. 27292124 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 GeneticVariation group BEFREE In addition, MCP-1 -2518 AA genotype seems to associate with CRF originated from hypertension and atherosclerosis in our study population. 25655256 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 Biomarker group BEFREE We fractionated mouse mesenchymal stromal cell-conditioned media to identify the biologically active component affecting in vivo hypoxic signaling and determined that exosomes, secreted membrane microvesicles, suppressed the hypoxic pulmonary influx of macrophages and the induction of proinflammatory and proproliferative mediators, including monocyte chemoattractant protein-1 and hypoxia-inducible mitogenic factor, in the murine model of hypoxic pulmonary hypertension. 23114789 2013
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 Biomarker group CTD_human Induction of hemeoxygenase-1 attenuates the hypertension and renal inflammation in spontaneously hypertensive rats. 20667508 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 AlteredExpression group BEFREE Infusion of Ang II increased blood pressure (p < 0.001) but decreased vascular relaxation in response to acetylcholine, endothelial nitric oxide synthase (eNOS) and phosphorylated eNOS (peNOS) levels, and renal and plasma levels of adiponectin (p < 0.05); in contrast, plasma tumor necrosis factor-α and monocyte chemoattractant protein-1 levels increased. 20836698 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 Biomarker group RGD Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats. 18459944 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 GeneticVariation group BEFREE Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris, and hypertension. 19639050 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 GeneticVariation group BEFREE Association between the -2518G/A polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene and hypertension in Tunisian patients. 18977211 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 Biomarker group BEFREE People with hypertension display an inflammatory pattern that includes increased plasma concentrations of monocyte chemoattractant protein 1 (MCP-1) and C-reactive protein (CRP) and enhanced expression of tissue factor (TF) mRNA in blood monocytes. 18339698 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 Therapeutic group RGD Angiotensin AT1 receptor antagonists exert anti-inflammatory effects in spontaneously hypertensive rats. 17922026 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 Biomarker group RGD TNF-alpha inhibition reduces renal injury in DOCA-salt hypertensive rats. 17989143 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.580 AlteredExpression group BEFREE Deregulated expression of monocyte chemoattractant protein-1 (MCP-1) in arterial hypertension: role in endothelial inflammation and atheromasia. 16794480 2006