CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 Biomarker disease BEFREE Receiver-operating characteristic curve analysis demonstrated that urinary CD11b was superior to CD16b, the scavenger receptor CD163, and monocyte chemotactic protein-1 for the prediction of proliferative LN. 30712924 2019
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 Biomarker disease BEFREE Combined utilization of untimed single urine of MCP-1 and TWEAK as a potential indicator for proteinuria in lupus nephritis: A case-control study. 29668584 2018
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 AlteredExpression disease BEFREE The levels of monocyte chemoattractant protein-1 (MCP-1) in the serum and urine of 72 SLE patients (27 with LN and 45 without LN involvement) and 30 healthy individuals were studied to establish their clinical significance. 29181621 2018
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 GeneticVariation disease BEFREE A combined model of uMCP-1 and uTWEAK showed an AUC of 0.887, sensitivity of 86.67% and specificity of 80.00% to discriminate active LN, and an AUC of 0.778, sensitivity of 75.00% and specificity of 81.82% to discriminate LN with poor outcome, which are better than the utility of any markers individually. 29451067 2018
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 Biomarker disease BEFREE We investigated whether levels of urinary neutrophil gelatinase-associated lipocalin (NGAL), and monocyte chemoattractant protein 1 (MCP-1) are good biomarkers to differentiate patients with lupus nephritis among Latin-American systemic lupus erythematosus (SLE) patients. 29073812 2018
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 AlteredExpression disease BEFREE Conclusion Urinary KIM-1, NGAL, and MCP-1 levels were associated with kidney injury indices in lupus nephritis. 30020021 2018
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 Biomarker disease BEFREE Our study identifies the gene expression profile for macrophages and demonstrated the induction of CCL2 and CD38 in macrophages from patients with LN. 29458096 2018
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 AlteredExpression disease BEFREE Results Urine and serum levels of CCL2, CCL5 and CXCL10 were elevated in active LN as compared with disease remission (best discrimination for urine CXCL10 and CCL2) and correlated with LN activity. 29653499 2018
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 AlteredExpression disease BEFREE Urinary AGP, ceruloplasmin, VCAM-1, MCP-1 and LPGDS levels were significantly higher in those patients with active LN than in non-LN patients [all corrected p values (p <sub>c</sub>) < 0.05] across both cohorts. 27590021 2017
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 GeneticVariation disease BEFREE The current meta-analysis suggests that the MCP-1-2518A/G polymorphism is associated with an increased risk of LN, especially in the American population. 29390552 2017
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 Biomarker disease BEFREE Objectives The renal activity index for lupus (RAIL) score was developed in children with lupus nephritis as a weighted sum of six urine biomarkers (UBMs) (neutrophil gelatinase-associated lipocalin, monocyte chemotactic protein 1, ceruloplasmin, adiponectin, hemopexin and kidney injury molecule 1) measured in a random urine sample. 28361601 2017
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 Biomarker disease BEFREE Dual blockade of CCL2 and CXCL12 can be as potent as CYC to suppress the progression of proliferative lupus nephritis probably because the respective chemokine targets mediate different disease pathomechanisms, i.e. systemic autoimmunity and peripheral tissue inflammation. 29111236 2017
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 Biomarker disease BEFREE Dual blockade of CCL2 and CXCL12 can be as potent as CYC to suppress the progression of proliferative lupus nephritis probably because the respective chemokine targets mediate different disease pathomechanisms, i.e. systemic autoimmunity and peripheral tissue inflammation. 27392463 2016
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 GeneticVariation disease BEFREE Association of monocyte chemoattractant protein 1 (MCP-1) gene polymorphism with lupus nephritis in Egyptian patients. 26429331 2015
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 Biomarker disease BEFREE Urinary HER-2 was increased in LN and reflected disease activity, and its levels correlated with those of 2 other recognized LN biomarkers, MCP-1 and VCAM-1. 26016809 2015
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 AlteredExpression disease BEFREE Mizoribine itself selectively attenuated the expression of MCP-1 both mRNA and protein levels in MCs treated with poly IC; that is, a possible model of 'pseudoviral' infection, which may be involved in the pathogenesis of lupus nephritis. 24134561 2014
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 AlteredExpression disease BEFREE Conversely, overexpression of CCL2 in lupus MSCs restored their immunoregulatory ability for B cells in vitro and ameliorated the pathology of lupus nephritis and serological changes in MRL/lpr mice in vivo. 25339674 2014
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 GeneticVariation disease BEFREE The aim of our study was to evaluate the possible association of the polymorphism -2518 of the MCP-1 gene with the risk of developing SLE, manifesting lupus nephritis (LN) and with other clinical features of SLE in an Argentinean population. 22466290 2012
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 GeneticVariation disease BEFREE This meta-analysis on 3419 subjects indicates that no association exists between the MCP-1 -2518 A/G polymorphism and SLE or LN. 19941075 2010
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 Biomarker disease BEFREE These findings support that MCP-1 -2518 G/G is associated with LN but there was no association of this genotype with renal function or renal survival. 20231199 2010
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 Biomarker disease BEFREE Incubating IL-20 with mesangial cells upregulated the transcripts of CCL2 (MCP-1), CCL5 (RANTES), CXCL10 (IP-10), IL-6, iNOS, and ROS, all of which are involved in the pathogenesis of lupus nephritis. 18771958 2008
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 AlteredExpression disease LHGDN Larger prospective studies of paediatric LN are required to further evaluate MCP-1 and other markers of disease progression. 18495743 2008
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 GeneticVariation disease BEFREE In this study, we examined the role of a functional monocyte chemoattractant protein 1 (MCP-1) polymorphism in SLE and LN. 15188361 2004
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 Biomarker disease BEFREE In this study we assessed the significance of the MCP-1 gene in determination of the histological phenotype in lupus nephritis. 15119544 2004
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis
0.100 GeneticVariation disease LHGDN In this study, we examined the role of a functional monocyte chemoattractant protein 1 (MCP-1) polymorphism in SLE and LN. 15188361 2004