CCL2, C-C motif chemokine ligand 2, 6347

N. diseases: 1157; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE We previously showed that naringenin, a citrus flavonoid, suppressed macrophage infiltration into adipose tissue by inhibiting monocyte chemoattractant protein-1 (MCP-1) expression in the progression phase to high-fat diet (HFD)-induced obesity. 31218550 2020
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE We conclude hypoxia or obesity induces release of inflammatory TNFα and MCP-1 from mice primary adipocytes but the two environmental conditions do not synergize to worsen macrophage signal transduction or insulin responsiveness. 31677795 2020
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Combined treatment of PA and LPS in RAW264.7 cells mimics the situation of diabetes with obesity that has higher level of PA and LPS, MAPK/TLR4/ MCP-1 might be potential therapeutic targets for diabetes with obesity. 30909920 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Obese-ALI animals, compared to Obese-SAL, exhibited increased interventricular septum thickness (<i>p</i> = 0.003) and posterior wall thickness (<i>p</i> = 0.003) and decreased pulmonary acceleration time to pulmonary ejection time ratio (<i>p</i> = 0.005); no changes in lung mechanics, IL-6, TNF-α, TGF-β, PCIII, and PCI in lung tissue; increased IL-10 levels in lung homogenate (<i>p</i> = 0.007); reduced MCP-1 expression in blood neutrophils (<i>p</i> = 0.009); decreased TNF-α expression in blood (<i>p</i> = 0.02) and BALF (<i>p</i> = 0.008) neutrophils; and increased IL-10 expression in monocytes (<i>p</i> = 0.004). 31275296 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Moreover, the level of urinary monocyte chemoattractant protein‑1 (u‑MCP‑1) was increased in the participants with obesity, and it was positively correlated with free fatty acid (FFA), UACR and u‑NGAL. 30535458 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Obesity is associated to a low-grade inflammation that alters the expression of adiponectin, leptin, IL-6, Monocyte Chemotactic Protein 1 (MCP1), TRAIL, LIGHT/TNFSF14, OPG, and TNFα. 31130918 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Taken together, our results suggest that obesity promotes CNS inflammation in EAE through IL-6 and CCL-2 mediated the inflammatory cells infiltration. 31507583 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE We analysed the levels of cytokines (tumour necrosis factor [TNF] α and interleukins [ILs] 1β, 4, 6 and 10), chemokines (stromal cell derived factor 1α, monocyte chemoattract protein [MCP] 1, eotaxin and fractalkine) and growth factors (brain-derived neurotrophic factor, pro-fibrotic platelet-derived growth factor [PDGF-BB] and insulin-like growth factor 1) in serum of prepubertal children with obesity (61 girls/59 boys, 50% IR and 50% non-IR) and 32 controls. 30350467 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE In terms of therapeutic applications, implant of scaffolds designed to release resveratrol into the visceral fat decreases MCP-1 expression in mice fed a high fat diet, a molecule that drives both local and systemic inflammation during obesity. 30462474 2018
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE To further understand the characteristics of inflammation in the ovaries of obese women we analysed a panel of cytokines (IL6, IL10 and TNFα), adipokines (adiponectin, leptin and monocyte chemotactic factor 1 (MCP-1)) and acute phase proteins (C-Reactive Protein (CRP) and sICAM-1) in the ovarian follicular fluid obtained at oocyte aspiration from women (n = 48) who were lean, overweight or obese. 30174020 2018
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE It is not known to what extent inflammation precedes the development of obesity.MethodsIn a cohort of 882 infants born before 28 weeks of gestation, we examined relationships between concentrations of 25 inflammation-related proteins in blood obtained during the first two postnatal weeks and body mass index at 2 years of age.ResultsAmong children delivered for spontaneous indications (n=734), obesity was associated with elevated concentrations of four proteins (IL-1β, IL-6, TNF-R1, and MCP-1) on the first postnatal day; one protein (IL-6) on postnatal day 7; and two proteins (ICAM-3 and VEGF-R1) on postnatal day 14. 29244802 2018
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Overall, our findings support a model in which elevated FFAs in obesity create a milieu for TNF-α to trigger CCL2 production via the TLR4/TRIF/IRF3 signaling cascade, representing a potential contribution of FFAs to metabolic inflammation. 29632147 2018
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Lower ADIPOQ and higher TNF and MCP1 mRNA expression in visceral adipose tissue may be correlated with obesity and T2DM in the Uygur population. 27573980 2017
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE This article underlines the significance and involvement of the chemokine MCP-1 in the development of obesity, type 2 diabetes, and diabetic complications, with an emphasis on the role of plant metabolites in the regulation of this chemokine and thus the role in the prevention or therapy of diabetes. 28266270 2017
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE OVX and HF significantly reduced plasma levels of nitrate/nitrite (NOx), and mice developed obesity with visceral hypertrophic adipocytes and increased transcriptional levels of monocyte chemoattractant protein-1, TNF-α, and IL-6 in visceral fat tissues. 28196859 2017
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Levels of hs-CRP (P=0.029), TNF-α (P=0.036), IL-6 (P=0.042), oxidized LDL (P=0.036), and MCP-1 (P=0.039) increased from the MHNO to MHO to MONO to MOO phenotypes. 25478993 2015
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Obesity is associated with elevated monocyte chemoattractant protein-1 (MCP-1), a proinflammatory chemokine related to diabetes and cardiovascular disease. 25994074 2015
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE The visceral adipose tissue expression levels of APN in normal group was greater than those in obesity and T2DM groups, and visceral adipose tissue expression levels of TNF-α and MCP-1 in normal group were lower than those in obesity and T2DM groups (P < 0.01). 26273678 2015
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE Mouse and human skeletal muscles gain a distinct population of inflammatory macrophages upon HFD or obesity, linked to insulin resistance in humans and CCL2 availability in mice. 24030890 2014
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Insulin-stimulated total glucose disposal (TGD), plasma FFA species, muscle insulin signalling, IBα protein, c-Jun phosphorylation, inflammatory gene (toll-like receptor 4 and monocyte chemotactic protein 1) expression, and ceramide and diacylglycerol (DAG) content were measured in muscle from a group of obese and T2DM subjects before and after administration of the antilipolytic drug acipimox for 7 days, and the results were compared to lean individuals. 23529132 2013
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE The hypertrophied white adipose tissue (WAT) during human obesity produces inflammatory mediators, including cytokines (IL-6 and TNFα) and chemokines ([C-C motif] chemokine ligand 2 and IL-8). 23372021 2013
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE The purpose of this study was to identify loci regulating serum MCP-1 in obese Hispanic children from the Viva La Familia Study. 23017229 2012
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE Among the adipokines analyzed, the most notable finding was a 15% lower level of monocyte chemotactic protein-1 in HT users, particularly with respect to its suggested mediator role between obesity and insulin resistance. 22914204 2012
CUI: C0028754
Disease: Obesity
Obesity
0.600 AlteredExpression disease BEFREE The data provide important mechanistic information on the cause of hepatic injury in obese-HCV subjects including: (1) enhanced T helper-1 cytokine response patterns-to promote hepatocellular injury; (2) increased expression of the chemokines IP-10 and MCP-1 at both the mRNA and protein levels-to enhance inflammatory cell recruitment; (3) differing localisation of these chemokines within the liver of obese-HCV versus lean-HCV subjects-implying different inducing stimuli and; (4) increased CD3 expression in the liver of obese-HCV subjects-concordant with the increased expression of T cell chemoattractants. 19289381 2010