CCL5, C-C motif chemokine ligand 5, 6352

N. diseases: 514; N. variants: 6
Disease: Dermatitis, Atopic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.390 Biomarker disease BEFREE The objective of this study was to evaluate the relationships of RANTES and RA and AD using a meta-analysis. 25607251 2015
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.390 GeneticVariation disease BEFREE We show that miR-146a expression is increased in keratinocytes and chronic lesional skin of patients with AD. miR-146a inhibited the expression of numerous proinflammatory factors, including IFN-γ-inducible and AD-associated genes CCL5, CCL8, and ubiquitin D (UBD) in human primary keratinocytes stimulated with IFN-γ, TNF-α, or IL-1β. 24996260 2014
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.390 Biomarker disease CTD_human Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis. 18249437 2008
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.390 GeneticVariation disease LHGDN These results support a role for RANTES promoter polymorphisms in susceptibility to atopic dermatitis. 17117952 2006
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.390 GeneticVariation disease BEFREE These results support a role for RANTES promoter polymorphisms in susceptibility to atopic dermatitis. 17117952 2006
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.390 GeneticVariation disease BEFREE G-401A polymorphism in RANTES promoter was associated with near-fatal asthma and atopic dermatitis in children. 15715189 2005
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.390 Biomarker disease BEFREE After treatment with topical tacrolimus twice daily for 8 weeks, significant decreases were found in serum IL-5 levels, immunoreactive cell counts of eotaxin, IL-5, CCR3 and RANTES in AD skin, and tissue eosinophil counts. 15948978 2005
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.390 AlteredExpression disease BEFREE Our results show that some of the skin lesions of beige rats are morphologically similar to human AD, being characterized by inflammatory cell composition in the acute phase, and increased IgE and RANTES levels. 15591815 2005
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.390 Biomarker disease BEFREE RANTES and MCP-1 mRNA(+) keratinocytes were detected in the basal layer of lesions of patients with AD and psoriasis. 11344355 2001
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.390 GeneticVariation disease BEFREE Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES. 10640782 2000
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.390 Biomarker disease BEFREE These findings suggest that RANTES is involved in eosinophil infiltration and T cell infiltration in atopic dermatitis. 8906106 1996