CCL5, C-C motif chemokine ligand 5, 6352

N. diseases: 514; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.240 Biomarker disease BEFREE Obesity is considered a chronic inflammatory disease, the inflammatory factors, such as interleukin 6 (IL-6), monocyte chemoattractant protein 1 (MCP-1) and small inducible cytokine A5 (RANTES), are elevated in obese individuals. 31270932 2019
CUI: C0028754
Disease: Obesity
Obesity
0.240 GeneticVariation disease BEFREE This present work aims the identification of the adipokines (leptin and resistin), chemokines (CCL2, CCL5, CXCL16) and the BMP-2 and their association with the clinical, biochemical (fasting glucose, hemogram, cholesterol, T3, T4 and TSH) and anthropometric (weight, height, body circumferences, skinfold thickness and percentage of body fat) parameters in young adults (18-30 years old) presenting obesity and overweight. 29763838 2018
CUI: C0028754
Disease: Obesity
Obesity
0.240 AlteredExpression disease BEFREE CCL5 levels measured by enzyme immunoassay in serum and by real-time polymerase chain reaction in WAT were higher in obese compared to lean subjects. 19893003 2010
CUI: C0028754
Disease: Obesity
Obesity
0.240 AlteredExpression disease BEFREE Regulated on activation, normal T-cell expressed and secreted (RANTES)/chemokine(C-C motif) ligand (CCL5) is expressed by adipocytes, and serum levels of RANTES are increased in obesity and type 2 diabetes. 18426815 2008
CUI: C0028754
Disease: Obesity
Obesity
0.240 Biomarker disease RGD RANTES and MCP-1 serum levels were increased in obese vs lean Zucker rats and significantly reduced by long-term treatment with rimonabant, which slowed weight gain in rats with the metabolic syndrome. 18469848 2008