CCL11, C-C motif chemokine ligand 11, 6356

N. diseases: 250; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker disease BEFREE Budesonide inhibited airway hyperreactivity, eosinophil counts in the lung and bronchoalveolar lavage (BAL) and CCL11, IL-13, and IL-23p19 release in the BAL of mice sensitized and challenged with <i>Af</i> (<i>p</i> < 0.05). 31572383 2019
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker disease BEFREE These changes are mirrored in serum and should be considered in the light of the downmodulating role of CD26 in major chemokines related to the pathogenesis of asthma such as CCL11 (eotaxin), CCL5 (RANTES), and CXCL12a (SDF-1α). 29297467 2019
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression disease BEFREE Eosinophil chemokines eotaxin-1 and eotaxin-2 were significantly upregulated (false discovery rate [FDR] < 0.05) by approximately 2.1- and 1.4-fold in the asthma study and by 2.3- and 1.7-fold in the COPD study following benralizumab treatment. 30658649 2019
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker disease BEFREE Together, our findings suggested that PM2.5 could exacerbate asthma by aggravating M2-polarization, highlighting for the first time that Eotaxin-1 released from M2 macrophages plays a crucial role in asthma pathogenesis. 30596560 2019
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression disease BEFREE CCR3 is the cognate receptor for major human eosinophil chemoattractants from the eotaxin family of proteins that are elevated in asthma and correlate with disease severity. 29423947 2018
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker disease BEFREE Sputum eotaxin and IL-4 concentrations in luteal phase were increased in PMA patients when compared with non-PMA asthmatics (P=0.016; P=0.041, respectively) and healthy subjects (P<0.001 both cytokines). 28840001 2017
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker disease BEFREE It also evaluates TNF-induced eotaxin synthesis in peripheral blood mononuclear cells from 14 patients with mild asthma and 13 healthy controls. 29128815 2017
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker disease BEFREE Eotaxin/CCL-11 is a major chemoattractant that contributes to eosinophilic inflammation in asthma. 28102022 2017
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker disease BEFREE More interestingly, eight major putative targets of YHQFC (interleukin [IL]-3, IL-4, IL-5, IL-10, IL-13, FCER1G, CCL11, and EPX) were demonstrated to be associated with the inflammatory process that occurs during the progression of asthma. 28053519 2017
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression disease BEFREE The adjusted ORs (95%CI) of association between IL-17A, IL-9, adipsin and CCL11 expressions and adult asthma were 3.08 (1.91, 4.97), 1.93 (1.41, 2.64), 10.02 (6.99, 14.37) and 3.29 (2.36, 4.59), respectively (all P <sub>trend</sub> < 0.0001). 29138487 2017
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression disease BEFREE The eotaxin receptor CCR3 was expressed at high levels on submucosal endothelial cells in patients and a murine model of asthma. 26810221 2016
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker disease BEFREE Here, we used NMR and fluorescence anisotropy to study the interaction between vCCI and eotaxin-1 (CCL11), a CC chemokine that is an important factor in the asthma response. 24482230 2014
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker disease BEFREE Our data demonstrate that: 1) Asthmatic HBEC exhibit an exaggerated apical, but not basal, secretion of TSLP after dsRNA exposure; 2) TSLP exposure induces unidirectional (apical) secretion of CCL11/eotaxin-1 in asthmatic HBEC and enhanced CCL11/eotaxin-1 secretion in asthmatic HASMC; 3) Rhinovirus-induced asthma exacerbations in children are associated with in vivo airway secretion of TSLP and CCL11/eotaxin-1. 25546419 2014
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker disease BEFREE Asthmatics with glutathione S-transferase P1 Val(105)/Val(105) compared with asthmatics with the glutathione S-transferase P1 Val(105)/Ile(105) and Ile(105)/Ile(105) had greater generation of acute phase cytokines (TNF-α, IL-6, CXCL8), IL-12, CCL11, thromboxane B2 and immunoglobulin E at 24 h after local allergen challenge. 23600543 2013
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression disease BEFREE We studied the correlation between the eotaxin gene expression level in the material from nasal brushing and respiratory tests in asthma and COPD patients. 22846146 2012
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker disease BEFREE CCL11 release was higher in ASMCs of patients with nonsevere but not severe asthma and nonasthmatic control subjects; CXCL8 and CX3CL1 release were similar in all groups. 22947346 2012
CUI: C0004096
Disease: Asthma
Asthma
0.700 Therapeutic disease RGD Twenty-four hours after asthma was induced, lung histomorphological changes, cells in bronchoalveolar lavage fluid (BALF), contents of eotaxin, MCP-1, and IL-8 in BALF, and the expression of IFN-γ and IL-4 mRNAs were observed. 22932891 2012
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression disease BEFREE These results indicate that Th2 cytokines and TGF-beta may contribute to the pathogenesis of asthma by stimulating expression of CCL11. 20214667 2010
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker disease BEFREE In this study we investigated serum samples from 944 individuals of 218 asthma-affected families by a multiplex, microsphere based system detecting at high sensitivity eleven asthma associated mediators: eotaxin (CCL11), granulocyte macrophage stimulating factor (GM-CSF), interferon gamma (IFNγ), interleukin-4 (IL-4), IL-5, IL-8, IL-10, IL-12 (p40), IL-13, IL-17 and tumor necrosis factor alpha (TNFα). 21179211 2010
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation disease BEFREE The detection of statistical interaction models is one evidence of gene-gene interactions among Eotaxin genes, and this interaction is thought to influence the development of asthma. 18712274 2008
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation disease LHGDN The detection of statistical interaction models is one evidence of gene-gene interactions among Eotaxin genes, and this interaction is thought to influence the development of asthma. 18712274 2008
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation disease BEFREE But, we observed that the A-384G polymorphism of Eotaxin 1 gene and T51C polymorphism of CCR3 gene are not associated with asthma. 17845580 2007
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation disease BEFREE Most interestingly, for the first time, a highly significant association of the newly studied (GAAGGA)(n) hexanucleotide repeat with asthma (p = 3x10(-6)), log(10)TsIgE (p = 0.006) and eotaxin levels (p = 0.004) was observed. 17220216 2007
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation disease LHGDN But, we observed that the A-384G polymorphism of Eotaxin 1 gene and T51C polymorphism of CCR3 gene are not associated with asthma. 17845580 2007
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression disease LHGDN Most interestingly, for the first time, a highly significant association of the newly studied (GAAGGA)(n) hexanucleotide repeat with asthma (p = 3x10(-6)), log(10)TsIgE (p = 0.006) and eotaxin levels (p = 0.004) was observed. 17220216 2007