|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Nod2 protects the gut from spreading colitis to small intestine.
|
31784737 |
2019 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, we investigated whether Nod2-deficiency influenced response of the gut microbiota to antibiotics and subsequent colitis susceptibility.
|
30651577 |
2019 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
We evaluated the effect of CD1d modulation on experimental colitis in NOD2-/- mice.
|
31094420 |
2019 |
|
Colitis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These studies thus suggest that NOD1- or NOD2-independenent activation of RICK plays a major role in both murine experimental colitis and human IBD.
|
31132297 |
2019 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Vitamin D Reduces Colitis- and Inflammation-Associated Colorectal Cancer in Mice Independent of NOD2.
|
28045548 |
2018 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In co-housed mice the acquisition of Rickenellaceae by Nod2+/+ mice was associated with increased CD4+ LAP+ Foxp3- proportion and less severe colitis.
|
30250234 |
2018 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Remarkably, Nod2 deletion improved both chronic cobblestone ileitis (by 50% assessed, as the % of abnormal mucosa at 24 wks of age), as well as acute dextran sodium sulfate (DSS) colitis.
|
27848951 |
2017 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
We reveal that OMVs require IBD-associated genes, ATG16L1 and NOD2, to activate a noncanonical autophagy pathway during protection from colitis.
|
27230380 |
2016 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Similarly, infection of Nod1-/- and Nod1/Nod2 double-knockout mice revealed that both Nod1 and Nod2 play a protective role in S. Typhimurium ΔmsbB-induced colitis.
|
25423082 |
2014 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
These results show for the first time that NOD2 plays a significant role in HCMV replication and may provide a model for studies of HCMV recognition by the host cell and HCMV colitis in Crohn's disease.
|
24671169 |
2014 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Pellino3-deficient mice had less induction of cytokines after engagement of Nod2 and had exacerbated disease in various experimental models of colitis.
|
23892723 |
2013 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, we show that dysbiosis caused by Nod2 deficiency gives rise to a reversible, communicable risk of colitis and colitis-associated carcinogenesis in mice.
|
23281400 |
2013 |
|
Colitis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Nod2-/-, β-actin-hPepT1 transgenic/Nod2-/-, and villin-hPepT1 transgenic/Nod2-/- littermates had similar levels of susceptibility to DSS-induced colitis, indicating that hPepT1 overexpression increased intestinal inflammation in a NOD2-dependent manner.
|
21762661 |
2011 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The recent findings in IBD include the increasing number of IBD susceptibility genes, the demonstration that NOD2 and ATG16L1 are linked in one functional pathway and the role of IL-33/ST2 in colitis.
|
21099431 |
2011 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The finding that MDP administration prevents experimental colitis opens the door to the possibility that such treatment might quell Crohn's disease relapses in patients without NOD2 abnormalities.
|
19079230 |
2008 |
|
Colitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This was not true for colonic disease with ileal involvement (P = 0.35), or for isolated colitis in patients with NOD2/CARD15 mutations (P = 0.61).
|
17763471 |
2007 |
|
Colitis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Dmbt1(-/-) mice display enhanced susceptibility to dextran sulfate sodium-induced colitis and elevated Tnf, Il6, and Nod2 expression levels during inflammation.
|
17983803 |
2007 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Notably, Nod2-deficient mice experienced increased susceptibility to enteric infection and to antigen-specific colitis.
|
17379562 |
2007 |
|
Colitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We establish that some loci, notably the IBD3 and chromosome 3q linkage regions demonstrate contributions from both small intestine and colon cohorts, whereas others, notably the IBD1 (NOD2/CARD15) and IBD2 regions increase risk for small intestine or colon inflammation, respectively.
|
16542294 |
2006 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Thus, NOD2-deficient mice become susceptible to colitis as a result of increased TLR2 responses when they have the capacity to respond to an antigen expressed by mucosal bacteria.
|
16949315 |
2006 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
RGD |
In this study, we examined the kinetics of Card15/Nod2 expression in intestinal tissue during inflammation in the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-treated rat experimental colitis model.
|
16891783 |
2006 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Results from multiple logistic regression, after correction for covariates, showed that the influence of IBD5 on clinical outcome of CD was completely masked by that of CARD15, while the influence on more extensive colitis in UC patients was confirmed.
|
16454837 |
2006 |
|
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
NOD2/CARD15 was associated with ileal involvement, while presence of TNF-863A was inversely associated with ileal disease (OR = 0.42, p= 0.008) and positively associated with isolated colitis (OR = 2.16, p= 0.008, OR = 2.12, p= 0.03 corrected) and familial disease (p= 0.004).
|
15667501 |
2005 |