Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1319315
Disease: Adenocarcinoma of large intestine
Adenocarcinoma of large intestine
0.500 GenomicAlterations disease CGI
CUI: C1319315
Disease: Adenocarcinoma of large intestine
Adenocarcinoma of large intestine
0.500 CausalMutation disease CGI
CUI: C1319315
Disease: Adenocarcinoma of large intestine
Adenocarcinoma of large intestine
0.500 GeneticVariation disease UNIPROT
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.360 AlteredExpression disease BEFREE In our study, MAP2K4 and Vimentin co-expression is confirmed to be an unfavorable factor in breast cancer. 31761784 2019
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.360 Biomarker disease BEFREE Our findings support the notion that selective activation of tumor-suppressive MEKK4-MKK4-p38-p21signaling pathway by triptonide is a new approach for pancreatic cancer therapy, providing a new drug candidate for development of novel anti-cancer therapeutics. 31075266 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.360 AlteredExpression disease BEFREE In our study, MAP2K4 and Vimentin co-expression is confirmed to be an unfavorable factor in breast cancer. 31761784 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.360 Biomarker disease BEFREE To determine the role of the MEKK1/SEK1/JNK1/AP-1 pathway in the action of Xihuang pill (XHP) in reducing regulatory T (Treg) cell numbers in the tumor microenvironment in a 4T1 mouse breast cancer model, and to clarify the anti-tumor mechanism of XHP in breast cancer. 29710529 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.360 Biomarker disease BEFREE To determine the role of the MEKK1/SEK1/JNK1/AP-1 pathway in the action of Xihuang pill (XHP) in reducing regulatory T (Treg) cell numbers in the tumor microenvironment in a 4T1 mouse breast cancer model, and to clarify the anti-tumor mechanism of XHP in breast cancer. 29710529 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.360 GeneticVariation disease BEFREE In this study, we found an inverse association between MKK4 promoter polymorphism and breast cancer risk. 27509166 2016
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.360 GeneticVariation disease BEFREE In this study, we found an inverse association between MKK4 promoter polymorphism and breast cancer risk. 27509166 2016
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.360 AlteredExpression disease BEFREE Pancreatic cancer tissues analysis showed that PTEN and MAP2K4 were all negatively correlated with miR-181a. 24532253 2014
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.360 GeneticVariation disease BEFREE In contrast, only three known cancer genes were found among male breast cancers; MAP2K4, LHP, and ZNF217. 24194916 2013
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.360 GeneticVariation disease BEFREE Our results demonstrate for the first time that common variants in BRCA2 and MAP2K4 are susceptibility to sporadic pancreatic cancer. 23299404 2013
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.360 AlteredExpression disease BEFREE Emerging data from a variety of investigators now indicate that overexpression of EphA2, loss of DPC4 and MKK4, and aberrant activation of the Hedgehog signaling pathway are associated with metastatic propensity of pancreatic cancers, providing novel therapeutic targets for the most lethal stage of this disease. 19260747 2009
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.360 Biomarker disease BEFREE The Metastasis Suppressor Genes (MSG) Nm23, KISS1, KAI1, BRMS1, and Mkk4 have been associated with the metastatic potential of breast cancer in vitro and in vivo. 15592684 2005
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.360 Biomarker disease BEFREE The Metastasis Suppressor Genes (MSG) Nm23, KISS1, KAI1, BRMS1, and Mkk4 have been associated with the metastatic potential of breast cancer in vitro and in vivo. 15592684 2005
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.360 AlteredExpression disease BEFREE MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course. 15623633 2004
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.360 Biomarker disease BEFREE To address this question, we studied an independent panel of 20 breast cancer cell lines and xenografts for MAP2K4 alterations. 11754110 2002
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.360 GeneticVariation disease BEFREE No mutations were identified in mitogen-activated protein kinase kinase 4 (0 of 22), MADH4 (0 of 22), or ACVR1B (0 of 29), making it unlikely that germ-line mutations in these genes account for a significant number of inherited pancreatic cancers. 12097290 2002
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.360 Biomarker disease BEFREE To address this question, we studied an independent panel of 20 breast cancer cell lines and xenografts for MAP2K4 alterations. 11754110 2002
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.360 Biomarker disease BEFREE Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. 9622070 1998
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.360 GenomicAlterations disease CGI
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.360 CausalMutation disease CGI
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.360 CausalMutation disease CGI
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.360 GenomicAlterations disease CGI