Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.090 AlteredExpression disease BEFREE MEK4 regulates MMP-2 expression, drives PCa metastasis, and genistein inhibits MEK4, decreases MMP-2 expression and dietary dosing inhibits human PCa metastasis in mice. 30917169 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.090 AlteredExpression disease BEFREE MAP2K4 was highly expressed in PCa tissues and inversely correlated with the miR‑136 expression level. 29328468 2018
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.090 Biomarker disease BEFREE In conclusion, miR-27a functions as a tumor suppressor by suppressing MAP2K4 which acts as an oncogene in prostate cancer cell lines; we also provided a new mechanism of castration-resistant prostate cancer mediated by miR-27a that downregulation of miR-27a caused by aberrant AR signaling and PI3K/Akt signaling after androgen deprivation therapy (ADT) would promote the progression of castration-resistant prostate cancer. 27594411 2016
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.090 AlteredExpression disease BEFREE To investigate, we engineered human PCa cell lines which overexpress either wild type or constitutive active MAP2K4. 25019290 2014
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.090 GeneticVariation disease BEFREE Role of the functional MKK4 promoter variant (-1304T>G) in a decreased risk of prostate cancer: case-control study and meta-analysis. 22526163 2012
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.090 Biomarker disease BEFREE We identified MEK4 as a proinvasion protein in six human prostate cancer cell lines and the target for genistein. 19638505 2009
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.090 AlteredExpression disease BEFREE Clinical correlative studies showed that MKK4 protein levels were reduced in high-grade prostate cancer and prostate and ovarian cancer metastases compared with normal tissue, which prompted investigation into the mechanism(s) responsible for down-regulation of MKK4 in a panel of cancer cell lines. 18337456 2008
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.090 AlteredExpression disease BEFREE These results demonstrate that MKK4 protein is consistently down-regulated during prostate cancer progression and support a role for dysregulation of its signaling cascade in clinical disease. 11306453 2001
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.090 Biomarker disease BEFREE Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17. 10554023 1999