|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Men with higher T, DHT or SHBG and higher PA had the lowest BMI, waist circumference and risk of metabolic syndrome.
|
30478933 |
2019 |
|
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
SHBG mRNA and protein levels were lower in patients with metabolic syndrome than in those without metabolic syndrome; however, these differences were significant only for mRNA level.
|
30496542 |
2019 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Low endogenous testosterone and sex hormone-binding globulin (SHBG) concentrations have been reported to be associated with metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD).
|
31068503 |
2019 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) and observational studies to assess the association between VD and MetS or its components (systolic blood pressure [SBP], diastolic blood pressure [DBP], fasting glucose triglycerides, waist circumference [WC], HDL-cholesterol (HDL-C)) in adults.
|
29907356 |
2019 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
In meta-regression analyses, the markers of metabolic syndrome diagnostic criteria (waist circumference, high-density lipoprotein cholesterol, triglyceride, blood pressure), BMI, glucose tolerance (2-hr oral glucose tolerance test) and surrogate markers of insulin resistance (HOMA-IR) but not markers of reproductive dysfunction (sex hormone binding globulin, testosterone, PCOS phenotypes) contributed significantly to the heterogeneity in the prevalence of metabolic syndrome.
|
30339316 |
2019 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
The associations of FAI, SHBG and AMH in relation to metabolic syndrome were significantly modified by BMI.
|
31444050 |
2019 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
This relationship was also observed in MetS components (BMI and SBP).
|
30157802 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
To examine whether expression of human <i>SHBG</i> in mice may ameliorate the development of diabetes and metabolic syndrome in response to a high-fat diet (HFD).
|
29141991 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The SHBG levels of the MetS group was significantly lower than non-MetS group 47.25±31.03 nmol/l vs. 56.55±37.84 nmol/l; p=0.013.
|
29245159 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Together, this body of evidence indicates that sex steroids and SHBG should be routinely incorporated into clinical characterization of T2D patients, particularly in screening prediabetic patients, such as those with metabolic syndrome, using plasma levels of SHBG.
|
27990781 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
J Strength Cond Res XX(X): 000-000, 2018-The purpose of this study was to identify and summarize the relationships between muscular fitness (MF) and individual components of metabolic syndrome (high waist circumference [WC], high blood pressure [BP], high systolic BP [SBP], high diastolic BP [DBP], high triglycerides [TG], fasting blood glucose [FG], and low HDL cholesterol levels [HDL-C]) in children and adolescents.
|
30273286 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Correlations between the levels of biochemical parameters and the levels of hormones in serum and the prostate tissue of BPH patients with and without MetS demonstrate that serum SHBG levels correlated weakly with waist size and triglyceride levels.
|
30122909 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Testosterone (free and total) and SHBG were significantly lower in MetS subjects and modestly reduced in type 2 DM with and without MetS.
|
30057912 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
MetS patients had lower levels of total testosterone (P = 0.001), sex hormone-binding globulin, inhibin B, and anti-Mόllerian hormone (all P ≤ 0.03), and they were hypogonadal at a higher prevalence (P = 0.01) than patients without MetS.
|
27004539 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lower levels of sex hormone-binding globulin increase risks of MetS and T2DM in both sexes.
|
29241756 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Simple logistic analysis showed that sex (OR 3.50, 95% CI 1.21-10.12, p = 0.021), age (OR 1.14, 95% CI 1.07-1.21, p<0.001), BMI (OR 1.11, 95% CI 1.01-1.22, p = 0.028), waist circumference (OR 1.06, 95% CI 1.02-1.10, p = 0.002), SBP (OR 1.03, 95% CI 1.01-1.04, p = 0.003), DBP (OR 1.03, 95% CI 1.00-1.06, p = 0.030), HDL-C (OR 0.97, 95% CI 0.94-1.00, p = 0.026), uric acid (OR 1.84, 95% CI 1.49-2.27, p<0.001), metabolic syndrome (OR 2.68, 95% CI 1.29-5.67, p = 0.009), and decreased BMD (OR 3.998, 95% CI 1.38-11.57, p = 0.011) were significantly associated with CKD.
|
29320555 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Baseline characteristics were similar in the two SBP target groups within each MetS subgroup, except body mass index was slightly higher in the standard arm of the MetS subgroup (33.3 ± 5.6 vs 33.0 ± 5.3 kg/m<sup>2</sup> ; P < .01), but were similar across treatment arms in the non-MetS subgroup.
|
29024310 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, SHBG suppresses inflammation and lipid accumulation in macrophages and adipocytes, which might be among the mechanisms underlying the protective effect of SHBG, that is, its actions which reduce the incidence of metabolic syndrome.
|
30046278 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MS: Metabolic syndrome; WC: Waist circumference; TG: Triglycerides; HDL-c: High-density lipoprotein cholesterol; BP: Blood pressure; SBP: Systolic blood pressure, DBP: Diastolic blood pressure; PA: Physical activity; JIS: Joint Interim Statement; CVD: Cardiovascular disease; ATP III: US Third Report of the National Cholesterol Education Program, the Adult Treatment Panel; IDF: International Diabetes Federation; IPAQ: International Physical Activity Questionnaire; BMI: Body mass index; CDC: the Nantong Centers for Disease Control; OR: Odds ratio; CI: Confidence interval; SD: Standard deviation; IQR: Interquartile range.
|
29345215 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
AGHD = adult growth hormone deficiency; ASCVD = atherosclerotic cardiovascular disease; AUROC = area under the receiver operating characteristic curve; BMI = body mass index; CVAI = Chinese visceral adiposity index; CVD = cardiovascular disease; DBP = diastolic blood pressure; GH = growth hormone; GHRT = GH replacement therapy; HDL-C = high-density lipoprotein cholesterol; IGF-1 = insulin like factor-1; IGFBP-3 = insulin like factor binding protein-3; IR = insulin resistance; LAP = lipid accumulation product; MS = metabolic syndrome; SBP = systolic blood pressure; TC = total cholesterol; TG = triglycerides; VAI = visceral adiposity index; WC = waist circumference; WHR = waist-to-hip ratio.
|
29144802 |
2018 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Besides, sex, age, WC, SBP, DBP, ALT, FG, UAC, TG, HDL-C and LDL-C are risk factors for MetS after multivariate adjustment.
|
28740055 |
2017 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, SHBG served as a major predictor for the risk of MetS and was correlated with serum adiponectin and leptin levels that are independent of T. Further studies are needed to elucidate the true role of SHBG in the pathogenesis of MetS and possible mechanisms associated with serum adiponectin and leptin levels.
|
28577342 |
2017 |
|
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Eight of them were normotensive and eleven hypertensive according to MetS threshold (≥130 mmHg for SBP and/or ≥85 mmHg for DBP).
|
28493030 |
2017 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study aimed at assessing associations between LAP and metabolic syndrome (MetS) and its components, age-related testosterone deficiency syndrome (TDS), low-density cholesterol (LDL), as well as HOMA-IR (insulin resistance ratio), insulin level in non-diabetics and total testosterone (TT), estradiol E<sub>2</sub>, dehydroepiandrosterone sulphate (DHEAs) and sex hormone-binding globulin (SHBG) in aging men.313 men aged 50-75 were surveyed with regard to the prevalence of diabetes (T2DM) and hypertension (HT).
|
27898988 |
2017 |
|
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
As such, the synthesis of SHBG could be associated with liver function and metabolic syndrome.
|
28540984 |
2017 |