Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.040 Biomarker group BEFREE We identified novel associations between SNPs in CD320 and DNMT2, which had been previously associated with neural tube defects, and vitamin B-12 status, as well as between SNPs in SHMT1, which had been previously associated with colorectal cancer and cardiovascular disease risk, and RBC folate status. 25948668 2015
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.040 Biomarker group BEFREE Using a cohort study design, we investigated whether sequence variants in the network of folate-related genes, particularly in genes encoding proteins related to SHMT1, predict CVD risk in 1131 men from the Normative Aging Study. 22649255 2012
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.040 GeneticVariation group BEFREE The association of genetic variation in the SHMT1 gene, alone and in interaction with MTHFR, in relation to CVD risk is relatively understudied at the population level and results in the NHS confirmed a past report of gene-gene interaction, which is consistent with mechanisms suggested by basic science studies. 21178087 2011
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.040 GeneticVariation group BEFREE Among men with cSHMT 1420C-->T TT genotype, the odds ratios (OR) for CVD risk for MTHFR 677C-->T CT and TT genotypes compared with the MTHFR 677C-->T CC genotype were 3.6 (95% CI, 1.7-7.8) and 10.6 (95% CI, 2.5-46.0), respectively. 16046727 2005