|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.
|
28552196 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, Siah-1 appears to be correlated with clinicopathological data, particularly tumor size.
|
27616748 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SIAH1 and SIAH2 have been found to function as a tumour repressor and a proto-oncogene, respectively, despite the high sequence identity of their substrate binding domains (SBDs).
|
27776223 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
On the contrary, silencing of miR-107 increased SIAH1 expression and inhibited the tumor growth of MDA-MB-231 cells, a kind of triple-negative breast cancer (TNBC) cells, in vitro and in vivo.
|
25851994 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We report here, that Siah1 was expressed highly in human glioma tissues compared with its expression in normal brain tissues and was correlated with advanced tumor status and stage.
|
25572001 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of SIAH1 in breast cancer is still ambiguous; both tumorigenic and tumor suppressive functions have been reported.
|
26654769 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The observed effects were due to the inhibitory action of miR-135a on its direct target seven in absentia homolog 1 (SIAH1) leading to upregulation of β-catenin/T cell factor signaling. miR-135a force-expression enhanced the growth of HeLa- and NC104-E6/E7-derived tumor in vivo.
|
24503442 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We analysed Siah1 expression as well as LMP1 and HIF1α expression by immuno-histochemical staining in 74 NPC biopsy specimens and found that the expression of Siah1 was significantly correlated with advanced tumour status and stage.
|
23228635 |
2013 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
S100P has been shown to mediate tumor growth, metastasis and invasion through the binding of Ca(2+) ions, receptor for advanced glycation end products, cytoskeletal protein ezrin, calcyclin-binding protein/Siah-1-interacting protein and cathepsin D. S100P could potentially serve as diagnostic marker, prognostic/predictive indicator and therapy target for different carcinomas.
|
21947242 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Nuclear accumulation of the E3 ubiquitin ligase SIAH-1 supports different pro-tumorigenic cellular processes associated with tumor growth and tumor cell dissemination in human hepatocarcinogenesis.
|
21356256 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We show that c-MYB is targeted by miR-155 and miR-424, that the tumor suppressor SIAH1 is targeted by miR-424, and that c-SKI is potentially regulated by miR-155.
|
21062812 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that development of drugs augmenting Siah1 and Siah1L activity could be a novel approach in improving tumor cell kill.
|
20682032 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SIAH1 was significantly downregulated in advanced HCCs, including poorly differentiated tumors, larger tumors, and tumors in advanced stages.
|
12557228 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These observations suggest SIAH1 as a candidate tumor suppressor gene that may be inactivated during tumorigenesis.
|
10956387 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1).
|
10393949 |
1999 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Therefore, <i>Tp53</i> mutation-Siah1-WISP1 is a new signaling pathway, playing an important role in pancreatic carcinogenesis.
|
30123132 |
2018 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
To investigate the role of nuclear translocation of calcyclin binding protein, also called Siah-1 interacting protein (CacyBP/SIP), in gastric carcinogenesis.
|
25110433 |
2014 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The inhibition of SIAH1 is in line with the notion that EBV impedes various pro-apoptotic pathways during tumorigenesis.
|
21062812 |
2011 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Thus, Siah1 is implicated in the regulation of HIF1alpha and is involved in a recently appreciated aspect of EBV-mediated tumorigenesis, namely, the angiogenesis process triggered by LMP1.
|
17047048 |
2006 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1.
|
12810624 |
2003 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
These observations suggest SIAH1 as a candidate tumor suppressor gene that may be inactivated during tumorigenesis.
|
10956387 |
2000 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Because the nuclear pattern of SIAH-2 differs in HCC tissues from the SIAH-1 pattern and because the inactivation of SIAH-2 is not compensated by SIAH-1, the specific inhibition of SIAH-2 (especially in combination with other drugs) represents a promising therapeutic strategy for HCC.
|
22323152 |
2012 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Therefore, Siah-1 may play important roles in ubiquitin-dependent degradation of HBx and may be involved in suppressing the progression of hepatocellular carcinoma (HCC).
|
21878328 |
2011 |
|
Liver carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
RNA interference revealed that nuclear expression of SIAH-1 predominantly supported HCC cell proliferation and migration while only moderately affecting anti-apoptosis.
|
21356256 |
2011 |