BMP3, bone morphogenetic protein 3, 651

N. diseases: 32; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker disease BEFREE When test results for BMP3 and NDRG4 were combined, the DOR of CRC detection was 98.36, which was higher than that for BMP3 and NDRG4 separately. 31097151 2020
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 PosttranslationalModification disease BEFREE In an analysis of stool samples from 3 independent studies of 332 patients with IBD, we associated levels of methylation at 2 genes (BMP3 and VAV3), relative to level of methylation at ZDHHC1, with detection of CRC and HGD. 29775793 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker disease BEFREE Though BMP3 is a reliable biomarker for screening CRC, the molecular mechanism of BMP3 in carcinogenesis remains largely unknown. 31665064 2019
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker disease BEFREE In this paper, we describe the recent advances in non-invasive CRC screening and more specifically in molecular assays for aberrantly methylated BMP3 and NDRG4 promoter regions. 26401070 2015
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 AlteredExpression disease BEFREE Ingenuity pathway analysis mapped three of these markers (GAS7, BMP3 and GPR) in the insulin and TGF-β1 network-the two key pathways in CRC. 24441198 2014
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker disease BEFREE The aim of this study was to investigate BMP3 disruption in CRCs in relation to both the traditional and serrated pathways of tumor progression. 18311777 2008
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.070 Biomarker disease BEFREE Four genes specifically methylated in colorectal cancer [bone morphogenetic protein 3 (BMP3), EYA2, aristaless-like homeobox-4 (ALX4), and vimentin] were selected from 41 candidate genes and evaluated on 74 cancers, 62 adenomas, and 70 normal epithelia. 18086775 2007