|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
WL women displayed decreased pro-inflammatory (NLRP3) but increased insulin-response gene (FASN and GLUT4) expression over time.
|
31164724 |
2020 |
|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although gonadotrophins and insulin increased GLUT-4 expression, neither modified 6-NBDG incorporation.
|
30955508 |
2019 |
|
Hyperinsulinism
|
0.100 |
Biomarker
|
disease |
BEFREE |
We propose that maternal insulin stimulates placental glucose transport by promoting GLUT4 trafficking to the BM, which may enhance glucose transfer to the fetus in response to postprandial hyperinsulinemia in women with normal BMI.
|
31112275 |
2019 |
|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We provided some mechanisms of action for osteocalcin in the amelioration of insulin resistance in obesity: in WAT, osteocalcin improves insulin resistance by decreasing inflammation, and increasing insulin signaling and the expression of Slc2a4/GLUT4; and, in bone, osteocalcin increases the secretion of uncarboxylated osteocalcin by improving insulin resistance.
|
29183784 |
2018 |
|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
E<sub>2</sub> induced (1) translocation of ESR1, but not of ESR2, from nucleus to plasma membrane and AKT phosphorylation, effects mimicked by PPT and blocked by MPP and PP2; (2) increased <i>Slc2a4</i>/GLUT4 expression and (3) increased insulin-stimulated GLUT4 translocation and glucose uptake.
|
28729437 |
2017 |
|
Hyperinsulinism
|
0.100 |
Biomarker
|
disease |
BEFREE |
TRG (50 mg/kg; p.o) lowered serum glucose, fructosamine, insulin, and HOMA-IR index and increased insulin sensitivity in soleus muscle via augmenting insulin receptor autophosphorylation (IR-PH), pT308-Akt, and glucose transporter 4 (GLUT4).
|
28271502 |
2017 |
|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In diabetes, energy excess and prolonged hyperinsulinemia suppress muscle and adipose response to insulin, in part through reduced GLUT4 membrane levels.
|
25215442 |
2015 |
|
Hyperinsulinism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest that hyperinsulinemia may inhibit GLUT4 by chronically maintaining GLUT4 in the Rab5 activity-dependent endosomal pathway and impairing formation of the TfR-negative and TfR-positive insulin-responsive GLUT4 pools.
|
24932807 |
2014 |
|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We aimed to estimate the response of glucose transporter 4 (GLUT4) and hexokinase-II (HKII) gene expression to hyperinsulinemia before and after surgical treatment with a BPD or dietary-induced weight loss.
|
23341487 |
2013 |
|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
GE treated groups improved the glucose tolerance, attenuated hyperglycemia and hyperinsulinemia in the mice by up-regulating the adiponectin and GLUT-4 gene expressions.
|
23259700 |
2012 |
|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hyperinsulinemia, associated with partial lipodystrophy, elevated RBP4, low adiponectin levels, and decreased expression of GLUT3 and GLUT4 were detected.
|
21883748 |
2012 |
|
Hyperinsulinism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we show in a model of chronic hyperinsulinemia that adipocytes develop selective insulin resistance in which translocation of the GLUT4 glucose transporter to the cell surface is blunted yet nuclear exclusion of the FoxO1 transcription factor is preserved, rendering uncoupled insulin-controlled carbohydrate and lipid metabolisms.
|
21646544 |
2011 |
|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Results show that whole body and tissue-specific indices of glucose utilization were: (1) augmented by GLUT4 overexpression, but not HKII overexpression, in the basal state; (2) enhanced by HKII overexpression in the presence of physiological hyperinsulinaemia; and (3) largely unaffected by GLUT4 overexpression during insulin clamps whether alone or combined with HKII overexpression.
|
15576451 |
2005 |
|
Hyperinsulinism
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data demonstrate that GLUT4 is present in the endometrium of normal and PCOS subjects and that hyperinsulinism and obesity seem to have a negative effect on endometrial GLUT4 expression in PCOS.
|
15292352 |
2004 |
|
Hyperinsulinism
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous work suggests that normal GLUT4 content is sufficient for increases in muscle glucose uptake (MGU) during hyperinsulinemia, because glucose phosphorylation is the more formidable barrier to insulin-stimulated MGU.
|
15284204 |
2004 |
|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
During the insulin clamp performed after 24 and 72 h of sustained physiological hyperinsulinemia, the ability of insulin to increase muscle GS fractional velocity, total body glucose disposal, and nonoxidative glucose disposal was impaired (all P < 0.01), whereas the effect of insulin on muscle HKII mRNA, HKII activity, GLUT-4 protein content, and whole body rates of glucose oxidation and glycolysis remained unchanged.
|
11287353 |
2001 |
|
Hyperinsulinism
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This point also became apparent by the development of only mild hyperinsulinaemia in mice with a targeted mutation in the Glut-4 gene.
|
10395191 |
1999 |
|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We report that expression of GLUT-4 is reduced in NIDDM and in obesity associated with hyperinsulinemia and insulin resistance.
|
7868815 |
1994 |
|
Hyperinsulinism
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Insulin increased GLUT-4 mRNA levels in all control subjects (from 68 +/- 5 to 92 +/- 6 pg/micrograms RNA; p < 0.0001), but not in the diabetic patients (from 99 +/- 8 to 90 +/- 8 pg/micrograms RNA, NS), or their relatives (from 94 +/- 9 to 101 +/- 11 pg/micrograms RNA, NS).
|
8063042 |
1994 |