|
Polycystic Ovary Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, berberine has the potential to reduce PCOS pathology and IR values in a rat model system through a mechanism linked to GLUT4 upregulation via PI3K/AKT activation and MAPK pathway suppression.
|
31778716 |
2020 |
|
Polycystic Ovary Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
For similar adiposity (BMI and waist-hip ratio), PCOS women tended to have higher HOMA-IR and lower Di and Si, and higher HOMA-β% and lower GLUT-4 than controls, while GLUT-1 was similar.
|
30623452 |
2019 |
|
Polycystic Ovary Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
A remarkable effect of quercetin was the intensive reduction of PCOS-IR and significant induction of uterine GLUT4 and ERα gene expression; it could thus be a possible effective treatment for PCOS and its complications, IR and infertility.
|
30103849 |
2019 |
|
Polycystic Ovary Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study explored the role of microRNA‑33b‑5p (miR‑33b‑5p) in PCOS pathogenesis, with a particular focus on its role in regulating glucose transporter 4 (GLUT4).
|
29693142 |
2018 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Therefore, the objective of this work was to evaluate TNF-α effect on expression of molecules associated with adiponectin (insulin sensitizing) and TNF-α signaling pathways and on Glucose Transporter type 4 (GLUT-4) levels in human endometrial cells under the characteristic conditions of hyperandrogenic/hyperinsulinic (HA/HI) PCOS.
|
28946816 |
2018 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PCOS was associated with lower expression of GLUT4 and IRS1 and a higher level of oxidative stress in VAT, which was strongly correlated with WC and HOMA-IR.
|
25064406 |
2014 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The RT-PCR experiments showed lower levels of GLUT4 mRNA transcripts in PCOS h-Ins compared with PCOS-MTF-treated group (P < 0.05), the protein levels of GLUT4 were decreased in a similar way.
|
23595973 |
2013 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In AT, analysis of the IRS/PI3-K/AKT pathway signaling components identified only GLUT4 expression to be significantly lower in PCOS patients and in control subjects with IR.
|
23493574 |
2013 |
|
Polycystic Ovary Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to evaluate whether the endocrine and metabolic status of PCOS modify the levels of gene and protein expression of FOXO1, PPARG, and SLC2A4 in the endometria from hyperinsulinemic PCOS women compared with controls.
|
20406953 |
2010 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study was performed to explore whether the well-known clinical, hormonal and metabolic efficacy of metformin or rosiglitazone treatment is reflected in the modulation of adipocyte GLUT4 mRNA expression in patients with PCOS.
|
18322300 |
2008 |
|
Polycystic Ovary Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate PIK3R1, SLC2A4, SLC2A4RG, and MEF2A to determine whether these genes are associated with susceptibility to polycystic ovary syndrome (PCOS) or key phenotypic features of insulin resistance in subjects with PCOS.
|
18249389 |
2008 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The similar results in lean PCOS and control subjects suggest that endometrial GLUT4 expression is not affected by PCOS itself, whereas it is reduced by obesity in PCOS patients.
|
15731326 |
2004 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
In conclusion, our data demonstrate that GLUT4 is present in the endometrium of normal and PCOS subjects and that hyperinsulinism and obesity seem to have a negative effect on endometrial GLUT4 expression in PCOS.
|
15292352 |
2004 |
|
Polycystic Ovary Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Western blot analysis showed that adipocyte levels of insulin receptor, PI3-kinase, and GLUT4 were respectively decreased by 56, 39.4 and 54% in PCOS patients compared with controls.
|
14688155 |
2004 |
|
Polycystic Ovary Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data demonstrate that GLUT4 is present in the endometrium of normal and PCOS subjects and that hyperinsulinism and obesity seem to have a negative effect on endometrial GLUT4 expression in PCOS.
|
15292352 |
2004 |