SLC6A2, solute carrier family 6 member 2, 6530

N. diseases: 238; N. variants: 24
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 Biomarker disease BEFREE This study demonstrates that clinically relevant doses of venlafaxine extended-release block the norepinephrine transporter of the major depressive disorder patient's brain. 30649319 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE Association between T-182C, G1287A polymorphism in NET gene and suicidality in major depressive disorder in Chinese patients. 29703117 2018
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 Biomarker disease BEFREE The authors tested norepinephrine transporter availability in patients with major depressive disorder with the aim to identify any associations between test results and clinical symptoms. 27631962 2017
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE NET rs2242446/T-182C may serve as a biomarker to predict the likelihood of remission with venlafaxine in older adults with major depression. 28068779 2017
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE Relationship between G1287A of the NET Gene Polymorphisms and Brain Volume in Major Depressive Disorder: A Voxel-Based MRI Study. 26960194 2016
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE We conducted an 8-week, open-label, prospective pilot study in 35 patients with major depressive disorder to assess the effects of genetic variations in SLC6A2 and SLC6A4 on both efficacy and side effect profile of desvenlafaxine. 27023264 2016
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE This study attempted to examine the relationship between polymorphisms of NET gene and MD. 26061302 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 Biomarker disease PSYGENET SLC6A2 variants may predict remission from major depression after venlafaxine treatment in Han Chinese population. 25512257 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE SLC6A2 variants may predict remission from major depression after venlafaxine treatment in Han Chinese population. 25512257 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 Biomarker disease PSYGENET Serotonin transporter (5-HTTLPR) and norepinephrine transporter (NET) gene polymorphisms: susceptibility and treatment response of electroconvulsive therapy in treatment resistant depression. 25650523 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 Biomarker disease PSYGENET This study attempted to examine the relationship between polymorphisms of NET gene and MD. 26061302 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 Biomarker disease PSYGENET Association between norepinephrine transporter gene (SLC6A2) polymorphisms and suicide in patients with major depressive disorder. 24655776 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE Association between norepinephrine transporter T-182C polymorphism and major depressive disorder: a meta-analysis. 24374057 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE Association between norepinephrine transporter gene (SLC6A2) polymorphisms and suicide in patients with major depressive disorder. 24655776 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 PosttranslationalModification disease BEFREE Methylation of the SLC6a2 gene promoter in major depression and panic disorder. 24312678 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE Association between major depressive disorder and the norepinephrine transporter polymorphisms T-182C and G1287A: a meta-analysis. 23648227 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 Biomarker disease PSYGENET Methylation of the SLC6a2 gene promoter in major depression and panic disorder. 24312678 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE In self-identified white patients with major depressive disorder (N=126) treated with open-label duloxetine (60-120 mg/d), a significant association of (P=0.020) of a composite risk score (based on SLC6A2 rs5569 [G1287A] AA, HTR1A rs6295 [C(-1019)G] GG, and COMT rs174697 AA/AG) with 17-item Hamilton Depression Rating Scale total score change from baseline to 12 weeks was observed. 22727709 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE 252 unrelated Caucasian patients (f = 142; m = 110) with major depression were genotyped for NET and 5-HTT polymorphisms. 20588071 2010
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 Biomarker disease BEFREE The norepinephrine transporter gene modulates the relationship between urban/rural residency and major depressive disorder in a Chinese population. 19564048 2009
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE The sample comprised 426 patients suffering from unipolar MD as well as 643 healthy control subjects for the variants of the 5-HT(1A) receptor and the NET. 19105200 2009
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE The present study suggests that the combined effect of rs2242446 and rs5569 in the NET gene could modify the response to the negative life events in triggering MD. 18779921 2008
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE This study suggests that the investigated polymorphisms in the NET gene are not major risk factors in increasing susceptibility to either major depression or its clinical subtypes in a Han Chinese population. 17353941 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE No association of the G1287A polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a Japanese population. 17917281 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.400 GeneticVariation disease BEFREE The NET T-182C polymorphism may be in part related to the pathophysiology of major depressive disorder in a Japanese population. 15539861 2004