SLC6A4, solute carrier family 6 member 4, 6532

N. diseases: 440; N. variants: 28
Disease: Melancholia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker disease PSYGENET An interaction between BDNF and ELS increased the risk of non-melancholia by 3.327, whereas the interaction between 5-HTT and ELS increased risk by 2.406. 22247094 2012
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 GeneticVariation disease BEFREE Key findings indicated that BDNF and 5-HTT polymorphisms in combination with ELS contributed to the development of non-melancholic depression. 22247094 2012
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker disease CTD_human Estradiol and progesterone modify the effects of the serotonin reuptake transporter polymorphism on serotonergic responsivity to citalopram. 21843009 2011
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker disease PSYGENET Norepinephrine and serotonin transporter genes: impact on treatment response in depression. 20588071 2010
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker disease CTD_human Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment. 18458677 2009
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 GeneticVariation disease BEFREE Also, the more active 5-HTTLPR/5-HTT rs25531 haplotype L(A)L(A) conveyed a significant risk for melancholic depression (OR 2.0; 95%CI 1.3-3.1; P=0.001), again only in the female subsample of patients (OR 2.1; 95%CI 1.1-4.1; P=0.02). 18050262 2008
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker disease PSYGENET Also, the more active 5-HTTLPR/5-HTT rs25531 haplotype L(A)L(A) conveyed a significant risk for melancholic depression (OR 2.0; 95%CI 1.3-3.1; P=0.001), again only in the female subsample of patients (OR 2.1; 95%CI 1.1-4.1; P=0.02). 18050262 2008
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker disease CTD_human The association between serotonin transporter gene promoter polymorphism (5-HTTLPR), self-reported symptoms, and dental mercury exposure. 18686203 2008
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker disease PSYGENET Melancholic depression was associated with the 5-HTTLPR long (l) allele and atypical depression with the 5-HTTLPR s-allele (two-sided Fisher's exact test: genotype distribution: P=0.0038; allele frequencies: P=0.007). 14593433 2003
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker disease CTD_human Regional serotonin transporter availability and depression are correlated in Wilson's disease. 12898347 2003
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 GeneticVariation disease BEFREE Melancholic depression was associated with the 5-HTTLPR long (l) allele and atypical depression with the 5-HTTLPR s-allele (two-sided Fisher's exact test: genotype distribution: P=0.0038; allele frequencies: P=0.007). 14593433 2003
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 GeneticVariation disease BEFREE According to these results, variability in the SERT gene has a small effect on liability to MDDM. 9799087 1998
CUI: C0025193
Disease: Melancholia
Melancholia 		0.540 Biomarker disease PSYGENET According to these results, variability in the SERT gene has a small effect on liability to MDDM. 9799087 1998